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Literature summary extracted from

  • Del Prete, S.; Vullo, D.; Scozzafava, A.; Capasso, C.; Supuran, C.T.
    Cloning, characterization and anion inhibition study of the delta-class carbonic anhydrase (TweCA) from the marine diatom Thalassiosira weissflogii (2014), Bioorg. Med. Chem., 22, 531-537.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 5-acetamido-1,3,4-thiadiazole-2-sulfonamide
-
 Conticribra weissflogii
4.2.1.1 hydrogen sulfide
-
 Conticribra weissflogii
4.2.1.1 phenylarsonic acid
-
 Conticribra weissflogii
4.2.1.1 phenylboronic acid
-
 Conticribra weissflogii
4.2.1.1 sulfamate
-
 Conticribra weissflogii
4.2.1.1 sulfamide
-
 Conticribra weissflogii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.1 32300
-
 calculated from cDNA Conticribra weissflogii

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Conticribra weissflogii
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.1 affinity chromatography Conticribra weissflogii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 Conticribra weissflogii H2CO3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 TweCA
-
 Conticribra weissflogii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.1.1 20
-
 assay at Conticribra weissflogii

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.1 130000
-
 CO2 pH 7.5, 20°C Conticribra weissflogii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.1 7.5
-
 assay at Conticribra weissflogii

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.000009
-
 phenylboronic acid pH 7.5, 20°C Conticribra weissflogii
4.2.1.1 0.000048
-
 sulfamide pH 7.5, 20°C Conticribra weissflogii
4.2.1.1 0.000076
-
 phenylarsonic acid pH 7.5, 20°C Conticribra weissflogii
4.2.1.1 0.000079
-
 sulfamate pH 7.5, 20°C Conticribra weissflogii
4.2.1.1 0.000083
-
 5-acetamido-1,3,4-thiadiazole-2-sulfonamide pH 7.5, 20°C Conticribra weissflogii
4.2.1.1 0.00009
-
 hydrogen sulfide pH 7.5, 20°C Conticribra weissflogii

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.2.1.1 33000
-
 CO2 pH 7.5, 20°C Conticribra weissflogii