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Literature summary extracted from
- Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity (2013), Bioorg. Med. Chem., 21, 1522-1525.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.1 | 2-bromo-benzenesulfonamide | - |
Ovis aries |  |
| 4.2.1.1 | 4-(2-aminoethyl) benzenesulfonamide | - |
Ovis aries | |
| 4.2.1.1 | 4-amino-6-chlorobenzene-1,3-disulfonamide | - |
Ovis aries | |
| 4.2.1.1 | 4-methylbenzenesulfonamide | - |
Ovis aries | |
| 4.2.1.1 | benzenesulfonamide | - |
Ovis aries | |
| 4.2.1.1 | mafenide | - |
Ovis aries | |
| 4.2.1.1 | naphthalene-2-sulfonamide | - |
Ovis aries | |
| 4.2.1.1 | saccharin | - |
Ovis aries | |
| 4.2.1.1 | sulfanilamide | - |
Ovis aries | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.1 | 0.01787 | - |
4-nitrophenyl acetate | Vmax: 0.168 micromol/min, pH 8.5, 35°C | Ovis aries | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.1 | 29000 | - |
SDS-PAGE | Ovis aries |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.1 | Ovis aries | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.2.1.1 | affinity chromatography | Ovis aries |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 4.2.1.1 | 20 mM Tris-HCl (pH 8.5) buffer, 14 days, 97 activity maintained | Ovis aries |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.1 | 4-nitrophenyl acetate + H2O | - |
Ovis aries | 4-nitrophenol + acetate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.1.1 | hCAII | - |
Ovis aries |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.1 | 35 | - |
- |
Ovis aries |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.1 | 8.5 | - |
- |
Ovis aries |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.1 | 0.001348 | - |
4-methylbenzenesulfonamide | pH 8.5, 35°C | Ovis aries | |
| 4.2.1.1 | 0.002586 | - |
naphthalene-2-sulfonamide | pH 8.5, 35°C | Ovis aries | |
| 4.2.1.1 | 0.0038 | - |
mafenide | pH 8.5, 35°C | Ovis aries | |
| 4.2.1.1 | 0.0045 | - |
4-amino-6-chlorobenzene-1,3-disulfonamide | pH 8.5, 35°C | Ovis aries | |
| 4.2.1.1 | 0.005874 | - |
2-bromo-benzenesulfonamide | pH 8.5, 35°C | Ovis aries | |
| 4.2.1.1 | 0.008664 | - |
benzenesulfonamide | pH 8.5, 35°C | Ovis aries | |
| 4.2.1.1 | 0.0096 | - |
4-(2-aminoethyl) benzenesulfonamide | pH 8.5, 35°C | Ovis aries | |
| 4.2.1.1 | 0.0315 | - |
saccharin | pH 8.5, 35°C | Ovis aries | |
| 4.2.1.1 | 0.06931 | - |
sulfanilamide | pH 8.5, 35°C | Ovis aries | |
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