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Literature summary extracted from

  • Akdemir, A.; Vullo, D.; De Luca, V.; Scozzafava, A.; Carginale, V.; Rossi, M.; Supuran, C.T.; Capasso, C.
    The extremo-alpha-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines (2013), Bioorg. Med. Chem. Lett., 23, 1087-1090.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.1 2-pyridylmethylamine moderate activator Sulfurihydrogenibium azorense
4.2.1.1 D-His moderate activator Sulfurihydrogenibium azorense
4.2.1.1 D-Phe high activator Sulfurihydrogenibium azorense
4.2.1.1 D-Trp high activator Sulfurihydrogenibium azorense
4.2.1.1 dopamine high activator Sulfurihydrogenibium azorense
4.2.1.1 L-adrenaline moderate activator Sulfurihydrogenibium azorense
4.2.1.1 L-Dopa high activator Sulfurihydrogenibium azorense
4.2.1.1 L-His moderate activator Sulfurihydrogenibium azorense
4.2.1.1 L-Phe moderate activator Sulfurihydrogenibium azorense
4.2.1.1 L-Trp high activator Sulfurihydrogenibium azorense
4.2.1.1 L-Tyr moderate activator Sulfurihydrogenibium azorense
4.2.1.1 serotonin high activator Sulfurihydrogenibium azorense

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Sulfurihydrogenibium azorense
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 Sulfurihydrogenibium azorense H2CO3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 alpha-carbonic anhydrase
-
 Sulfurihydrogenibium azorense
4.2.1.1 SazCA
-
 Sulfurihydrogenibium azorense

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.1.1 25
-
 assay at Sulfurihydrogenibium azorense

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.1 4400000
-
 CO2 pH 7.5, 25°C, without activator Sulfurihydrogenibium azorense
4.2.1.1 15000000
-
 CO2 pH 7.5, 25°C, 10 microM L-Phe Sulfurihydrogenibium azorense
4.2.1.1 33000000
-
 CO2 pH 7.5, 25°C, 10 microM D-Phe Sulfurihydrogenibium azorense

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.1 7.5
-
 assay at Sulfurihydrogenibium azorense