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Literature summary extracted from

  • Amissah, F.; Duverna, R.; Aguilar, B.J.; Poku, R.A.; Lamango, N.S.
    Polyisoprenylated methylated protein methyl esterase is both sensitive to curcumin and overexpressed in colorectal cancer: implications for chemoprevention and treatment (2013), BioMed Res. Int., 2013, 416534.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.1.1 pharmacology enzyme overexpression in colorectal cancer and cancer cell death stemming from its inhibition is an indication of its possible role in cancer progression and a target for chemopreventive agents Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.1 curcumin reversible inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.1 additional information
-
 additional information Michaelis-Menten kinetics analysis, overview Homo sapiens
3.1.1.1 0.0236
-
 N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester pH 7.4, 37°C, in absence of curcumin Homo sapiens
3.1.1.1 0.0853
-
 N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester pH 7.4, 37°C, in presence of curcumin Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.1 polyisoprenylated methylated protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.1 Caco-2 cell
-
 Homo sapiens
-
3.1.1.1 colon
-
 Homo sapiens
-
3.1.1.1 colorectal cancer cell enzyme overexpression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O specific enzyme substrate Homo sapiens ?
-
 ?
3.1.1.1 polyisoprenylated methylated protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.1 PMPMEase
-
 Homo sapiens
3.1.1.1 polyisoprenylated methylated protein methyl esterase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.1 7.4
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.1 0.0003
-
 curcumin pH 7.4, 37°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.1 0.0124
-
 pH 7.4, 37°C Homo sapiens curcumin

General Information

EC Number General Information Comment Organism
3.1.1.1 malfunction enzyme inhibition induces cancer cell death, enzyme inhibition by curcumin reduces colorectal cancer cell viability Homo sapiens
3.1.1.1 metabolism key enzyme in the polyisoprenylation pathway Homo sapiens