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Literature summary extracted from

  • Takishita, K.; Chikaraishi, Y.; Leger, M.M.; Kim, E.; Yabuki, A.; Ohkouchi, N.; Roger, A.J.
    Lateral transfer of tetrahymanol-synthesizing genes has allowed multiple diverse eukaryote lineages to independently adapt to environments without oxygen (2012), Biol. Direct, 7, 0000.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.123 phylogenetic analysis Tetrahymena pyriformis
4.2.1.123 phylogenetic analysis Paramecium tetraurelia
4.2.1.123 phylogenetic analysis Piromyces sp.
4.2.1.123 phylogenetic analysis Alvinella pompejana
4.2.1.123 phylogenetic analysis Paratrimastix pyriformis
4.2.1.123 phylogenetic analysis Stygiella incarcerata
4.2.1.123 phylogenetic analysis Sawyeria marylandensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.123 squalene + H2O Tetrahymena pyriformis
-
 tetrahymanol
-
 ?
4.2.1.123 squalene + H2O Paramecium tetraurelia
-
 tetrahymanol
-
 ?
4.2.1.123 squalene + H2O Piromyces sp.
-
 tetrahymanol
-
 ?
4.2.1.123 squalene + H2O Alvinella pompejana
-
 tetrahymanol
-
 ?
4.2.1.123 squalene + H2O Paratrimastix pyriformis
-
 tetrahymanol
-
 ?
4.2.1.123 squalene + H2O Stygiella incarcerata
-
 tetrahymanol
-
 ?
4.2.1.123 squalene + H2O Sawyeria marylandensis
-
 tetrahymanol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.123 Alvinella pompejana
-
-
-
4.2.1.123 Paramecium tetraurelia
-
-
-
4.2.1.123 Paratrimastix pyriformis
-
-
-
4.2.1.123 Piromyces sp.
-
-
-
4.2.1.123 Sawyeria marylandensis
-
-
-
4.2.1.123 Stygiella incarcerata
-
-
-
4.2.1.123 Tetrahymena pyriformis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.123 squalene + H2O
-
 Tetrahymena pyriformis tetrahymanol
-
 ?
4.2.1.123 squalene + H2O
-
 Paramecium tetraurelia tetrahymanol
-
 ?
4.2.1.123 squalene + H2O
-
 Piromyces sp. tetrahymanol
-
 ?
4.2.1.123 squalene + H2O
-
 Alvinella pompejana tetrahymanol
-
 ?
4.2.1.123 squalene + H2O
-
 Paratrimastix pyriformis tetrahymanol
-
 ?
4.2.1.123 squalene + H2O
-
 Stygiella incarcerata tetrahymanol
-
 ?
4.2.1.123 squalene + H2O
-
 Sawyeria marylandensis tetrahymanol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.123 squalene-tetrahymanol cyclase
-
 Tetrahymena pyriformis
4.2.1.123 squalene-tetrahymanol cyclase
-
 Paramecium tetraurelia
4.2.1.123 squalene-tetrahymanol cyclase
-
 Piromyces sp.
4.2.1.123 squalene-tetrahymanol cyclase
-
 Alvinella pompejana
4.2.1.123 squalene-tetrahymanol cyclase
-
 Paratrimastix pyriformis
4.2.1.123 squalene-tetrahymanol cyclase
-
 Stygiella incarcerata
4.2.1.123 squalene-tetrahymanol cyclase
-
 Sawyeria marylandensis
4.2.1.123 STC
-
 Tetrahymena pyriformis
4.2.1.123 STC
-
 Paramecium tetraurelia
4.2.1.123 STC
-
 Piromyces sp.
4.2.1.123 STC
-
 Alvinella pompejana
4.2.1.123 STC
-
 Paratrimastix pyriformis
4.2.1.123 STC
-
 Stygiella incarcerata
4.2.1.123 STC
-
 Sawyeria marylandensis

General Information

EC Number General Information Comment Organism
4.2.1.123 evolution genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview Tetrahymena pyriformis
4.2.1.123 evolution genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview Paramecium tetraurelia
4.2.1.123 evolution genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview Piromyces sp.
4.2.1.123 evolution genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview Alvinella pompejana
4.2.1.123 evolution genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview Paratrimastix pyriformis
4.2.1.123 evolution genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview Stygiella incarcerata
4.2.1.123 evolution genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview Sawyeria marylandensis
4.2.1.123 additional information tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments Tetrahymena pyriformis
4.2.1.123 additional information tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments Paramecium tetraurelia
4.2.1.123 additional information tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments Piromyces sp.
4.2.1.123 additional information tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments Alvinella pompejana
4.2.1.123 additional information tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments Paratrimastix pyriformis
4.2.1.123 additional information tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments Stygiella incarcerata
4.2.1.123 additional information tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments Sawyeria marylandensis