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Literature summary extracted from

  • Radovic, B.; Aflaki, E.; Kratky, D.
    Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis (2012), Biol. Chem., 393, 1005-1011.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.3 CGI-58 lipid droplet-binding protein Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.3 triacylglycerol + H2O Mus musculus
-
 diacylglycerol + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.3 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.3 brown adipose tissue
-
 Mus musculus
-
3.1.1.3 macrophage
-
 Mus musculus
-
3.1.1.3 white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.3 additional information the enzyme lacks the ability to hydrolyze monoacylglycerol, CEs, or retinyl esters Mus musculus ?
-
 ?
3.1.1.3 triacylglycerol + H2O
-
 Mus musculus diacylglycerol + a carboxylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.3 adipose triglyceride lipase
-
 Mus musculus
3.1.1.3 ATGL
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.1.3 malfunction enzyme-deficient mice show an increased utilization of carbohydrates as an energy source, leading to improved glucose tolerance and insulin sensitivity. Enzyme-deficient male mice are fertile, whereas females lack the ability to suckle their offspring due to impaired milk production. Enzyme-deficient mice exhibit defective thermogenesis in brown adipose tissue. Enzyme-deficient macrophages accumulate triacylglycerol-rich lipid droplets resulting in altered cell morphology that resemble macrophage foam cells. ATGL deficiency attenuates the mRNA expression of the proinflammatory chemokine (C-X-C motif) ligand 1 (Gro1) and the release of interleukin-6 from macrophages. Enzyme deficiency limits adipose tissue macrophage accumulation during fasting Mus musculus