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Literature summary extracted from

  • Meng, F.G.; Zhang, Z.Y.
    Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical (2013), Biochim. Biophys. Acta, 1834, 464-469.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 H2O2 the enzyme can be more rapidly inactivated by H2O2 in the absence of EDTA Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.48 [a protein]-tyrosine phosphate + H2O Homo sapiens
-
 [a protein]-tyrosine + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 4-nitrophenyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + phosphate
-
 ?
3.1.3.48 [a protein]-tyrosine phosphate + H2O
-
 Homo sapiens [a protein]-tyrosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 CD45
-
 Homo sapiens
3.1.3.48 HEPTP
-
 Homo sapiens
3.1.3.48 protein tyrosine phosphatase
-
 Homo sapiens
3.1.3.48 PTP1B
-
 Homo sapiens
3.1.3.48 PTPalpha
-
 Homo sapiens
3.1.3.48 VHR
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.48 0.006
-
 H2O2 PTP1B, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C Homo sapiens
3.1.3.48 0.0074
-
 H2O2 CD45, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C Homo sapiens
3.1.3.48 0.0075
-
 H2O2 HePTP, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C Homo sapiens
3.1.3.48 0.0294
-
 H2O2 VHR, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C Homo sapiens
3.1.3.48 0.196
-
 H2O2 PTPalpha, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C Homo sapiens