EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.1.19 | Mycobacterium tuberculosis | - |
- |
- |
6.3.1.19 | Mycobacterium tuberculosis ATCC 25618 | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
6.3.1.19 | recombinant His6-tagged enzyme expressed in Escherichia coli | Mycobacterium tuberculosis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.3.1.19 | PafA | ambiguous | Mycobacterium tuberculosis |
6.3.1.19 | Pup ligase | - |
Mycobacterium tuberculosis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
6.3.1.19 | metabolism | proteasome-containing bacteria possess a tagging system that directs proteins to proteasomal degradation by conjugating them to a prokaryotic ubiquitin-like protein (Pup). A single ligating enzyme, PafA, is responsible for Pup conjugation to lysine side chains of protein substrates. As Pup is recognized by the regulatory subunit of the proteasome, Pup functions as a degradation tag. Ligating enzyme PafA and the proteasome can function as a modular machine for the tagging and degradation of cytoplasmic proteins | Mycobacterium tuberculosis |