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Literature summary extracted from

  • Edson, K.Z.; Prasad, B.; Unadkat, J.D.; Suhara, Y.; Okano, T.; Guengerich, F.P.; Rettie, A.E.
    Cytochrome P450-dependent catabolism of vitamin K: omega-hydroxylation catalyzed by human CYP4F2 and CYP4F11 (2013), Biochemistry, 52, 8276-8285.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.78 expressed in Escherichia coli Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.78 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.78 menaquinone-4 + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 omega-hydroxymenaquinone-4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.78 phylloquinone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 omega-hydroxyphylloquinone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.78 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.78
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.78 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.78 menaquinone-4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens omega-hydroxymenaquinone-4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.78 phylloquinone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens omega-hydroxyphylloquinone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.78 CYP4F11
-
 Homo sapiens
1.14.14.78 CYP4F2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.78 NADPH
-
 Homo sapiens