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Literature summary extracted from

  • Jin, R.; Koop, D.R.; Raucy, J.L.; Lasker, J.M.
    Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4 (1998), Arch. Biochem. Biophys., 359, 89-98.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.78 additional information unaffected by lauric acid, palmitic acid, and prostaglandin F2alpha Homo sapiens
1.14.14.78 prostaglandin A1
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.78 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.78 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.78 tryptamine CH-Sepharose column chromatography, DE-53 cellulose column chromatography, and Hypatite C column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.78 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.78 arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.78 leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 20-hydroxyleukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.78 CYP4F2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.78 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.14.78 physiological function CYP4F2 is the principle leukotriene B4 omega-hydroxylating enzyme expressed in human liver and plays an important role in regulating circulating as well as hepatic levels of this powerful proinflammatory eicosanoid Homo sapiens