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Literature summary extracted from

  • Choi, W.S.; Wu, X.; Choeng, Y.H.; Mahmud, T.; Jeong, B.C.; Lee, S.H.; Chang, Y.K.; Kim, C.J.; Hong, S.K.
    Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838 (2008), Appl. Microbiol. Biotechnol., 80, 637-645.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.3.152 expression in Escherichia coli Streptomyces albus
4.2.3.152 overexpressed in Escherichia coli Streptomyces albus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.3.152 50500
-
 x * 50500, SDS-PAGE, His-tagged recombinant protein Streptomyces albus
4.2.3.152 50550
-
 x * 50550, polyhistidine-tagged protein, SDS-PAGE Streptomyces albus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.152 D-sedoheptulose 7-phosphate Streptomyces albus the enzyme is involved in biosynthesis of 2-epi-5-epi-valiolone a precursor in the biosynthesis of C7N-aminocyclitol-containing natural products, such as validamycin and acarbose 2-epi-5-epi-valiolone + phosphate
-
 ?
4.2.3.152 D-sedoheptulose 7-phosphate Streptomyces albus ATCC 21838 the enzyme is involved in biosynthesis of 2-epi-5-epi-valiolone a precursor in the biosynthesis of C7N-aminocyclitol-containing natural products, such as validamycin and acarbose 2-epi-5-epi-valiolone + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.152 Streptomyces albus A8D7K2
-
-
4.2.3.152 Streptomyces albus ATCC 21838 A8D7K2
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.3.152
-
 Streptomyces albus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.152 D-sedoheptulose 7-phosphate the enzyme is involved in biosynthesis of 2-epi-5-epi-valiolone a precursor in the biosynthesis of C7N-aminocyclitol-containing natural products, such as validamycin and acarbose Streptomyces albus 2-epi-5-epi-valiolone + phosphate
-
 ?
4.2.3.152 D-sedoheptulose 7-phosphate SalQ has high specificity for sedoheptulose 7-phosphate as substrate. No activity with D-glucose 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate, 3-deoxy-D-arabino-heptulosonate 7-phosphate and D-ribose 5-phosphate Streptomyces albus 2-epi-5-epi-valiolone + phosphate
-
 ?
4.2.3.152 D-sedoheptulose 7-phosphate the enzyme is involved in biosynthesis of 2-epi-5-epi-valiolone a precursor in the biosynthesis of C7N-aminocyclitol-containing natural products, such as validamycin and acarbose Streptomyces albus ATCC 21838 2-epi-5-epi-valiolone + phosphate
-
 ?
4.2.3.152 D-sedoheptulose 7-phosphate SalQ has high specificity for sedoheptulose 7-phosphate as substrate. No activity with D-glucose 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate, 3-deoxy-D-arabino-heptulosonate 7-phosphate and D-ribose 5-phosphate Streptomyces albus ATCC 21838 2-epi-5-epi-valiolone + phosphate
-
 ?
4.2.3.152 additional information no substrates: amino 3-deoxy-D-arabino-heptulosonate 7-phosphate, 3-deoxy-D-arabino-heptulosonate 7-phosphate, glucose 6-phosphate, fructose 6-phosphate, mannose 6-phosphate, and ribose 5-phosphate Streptomyces albus ?
-
 ?
4.2.3.152 additional information no substrates: amino 3-deoxy-D-arabino-heptulosonate 7-phosphate, 3-deoxy-D-arabino-heptulosonate 7-phosphate, glucose 6-phosphate, fructose 6-phosphate, mannose 6-phosphate, and ribose 5-phosphate Streptomyces albus ATCC 21838 ?
-
 ?
4.2.3.152 sedoheptulose 7-phosphate
-
 Streptomyces albus 2-epi-5-epi-valiolone + phosphate
-
 ?
4.2.3.152 sedoheptulose 7-phosphate
-
 Streptomyces albus ATCC 21838 2-epi-5-epi-valiolone + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.3.152 ? x * 50550, polyhistidine-tagged protein, SDS-PAGE Streptomyces albus
4.2.3.152 ? x * 50500, SDS-PAGE, His-tagged recombinant protein Streptomyces albus

Synonyms

EC Number Synonyms Comment Organism
4.2.3.152 SalQ
-
 Streptomyces albus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.3.152 30
-
 assay at Streptomyces albus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.3.152 7.5
-
 assay at Streptomyces albus

General Information

EC Number General Information Comment Organism
4.2.3.152 physiological function the enzyme is involved in biosynthesis of 2-epi-5-epi-valiolone a precursor in the biosynthesis of C7N-aminocyclitol-containing natural products, such as validamycin and acarbose Streptomyces albus