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Literature summary extracted from

  • Prydz, K.; Kase, B.F.; Bjoerkhem, I.; Pedersen, J.I.
    Subcellular localization of 3alpha,7alpha-dihydroxy- and 3alpha,7alpha,12alpha-trihydroxy-5beta-cholastanoyl-coenzyme A ligase(s) in rat liver (1988), J. Lipid Res., 29, 997-1004.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.2.1.7 bovine serum albumin activation Rattus norvegicus
6.2.1.7 dithiothreitol activation Rattus norvegicus
6.2.1.7 Triton X-100 activation Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.7 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
6.2.1.28 endoplasmic reticulum
-
 Rattus norvegicus 5783
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.7 Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.7 ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA Rattus norvegicus
-
 AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
-
 ?
6.2.1.28 ATP + 3alpha,7alpha-dihydroxy-5beta-cholestanate + CoA Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.7 Rattus norvegicus
-
-
-
6.2.1.28 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.7 liver
-
 Rattus norvegicus
-
6.2.1.28 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.2.1.7 0.0018
-
 activity of microsomal extraxt Rattus norvegicus
6.2.1.28 0.0015
-
 activity of microsomal fraction Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.7 ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA
-
 Rattus norvegicus AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
-
 ?
6.2.1.28 ATP + 3alpha,7alpha-dihydroxy-5beta-cholestanate + CoA
-
 Rattus norvegicus AMP + diphosphate + 3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA
-
 ?
6.2.1.28 ATP + 3alpha,7alpha-dihydroxy-5beta-cholestanate + CoA
-
 Rattus norvegicus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.7 7.7
-
-
 Rattus norvegicus