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Literature summary extracted from

  • Brito, V.B.; Folmer, V.; Guerra, I.I.; Rocha, J.B.
    Kinetics of alloxan-induced inhibition on delta-aminolevulinate dehydratase activity in mouse liver homogenates (2012), Appl. Biochem. Biotechnol., 166, 1047-1056.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.24 alloxan i.e. 2,4,5,6-tetraoxypyrimidine 5,6-dioxyuracil , 0.00125-0.02 mM alloxan causes a concentration-dependent uncompetitive inhibition. Dithiothreitol (0.7and 1 mM) completely prevents the inhibition induced by 0.01 and 0.02 mM alloxan. Similar protection is obtained in the presence of 2 mMglutathione Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.24 5-aminolevulinate Mus musculus
-
 porphobilinogen + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.24 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.24 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.24 5-aminolevulinate
-
 Mus musculus porphobilinogen + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.24 delta-ALA-D
-
 Mus musculus
4.2.1.24 delta-aminolevulinate dehydrataseALAD
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.24 0.00364
-
 alloxan pH 6.4 and 37°C Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.2.1.24 0.004
-
 pH 6.4 and 37°C Mus musculus alloxan

General Information

EC Number General Information Comment Organism
4.2.1.24 metabolism the enzyme catalyses the second step in heme biosynthesis Mus musculus