EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.32 | diethylstilbestrol | - |
Sus scrofa | |
1.14.14.32 | dioctyltin chloride | - |
Homo sapiens | |
1.14.14.32 | flusilazole | - |
Homo sapiens | |
1.14.14.32 | flusilazole | - |
Sus scrofa | |
1.14.14.32 | ketoconazole | - |
Homo sapiens | |
1.14.14.32 | ketoconazole | - |
Sus scrofa | |
1.14.14.32 | methylmercury | - |
Sus scrofa | |
1.14.14.32 | additional information | no effect by valproic acid, triclosan, tebuconazole, bisphenol A, tetrabromobisphenol A, methoxyacetic acid, cyclosporin A, endosulfan, methylmercury, perfluorobutane sulfonic acid, perfluorohexane sulfonic acid, perfluorononanoic acid, perfluorooctanoic acid, perfluorooctane sulfate, glufosinate ammonium, dibutyl phthalate, diethylhexyl phthalate, mono-ethylhexyl phthalate, epicatechin, genistein, D-mannitol, diethylstilbestrol, atrazine, retinoic acid, and 4-hydroxy-androstenedione | Homo sapiens | |
1.14.14.32 | additional information | no effect by valproic acid, triclosan, bisphenol A, methoxyacetic acid, cyclosporin A, forskolin, endosulfan, dioctyltin chloride, perfluorobutane sulfonic acid, perfluorohexane sulfonic acid, perfluorononanoic acid, perfluorooctanoic acid, perfluorooctane sulfate, glufosinate ammonium, dibutyl phthalate, diethylhexyl phthalate, mono-ethylhexyl phthalate, epicatechin, genistein, D-mannitol, atrazine, retinoic acid, and 4-hydroxy-androstenedione | Sus scrofa | |
1.14.14.32 | SU10603 | - |
Homo sapiens | |
1.14.14.32 | SU10603 | - |
Sus scrofa | |
1.14.14.32 | tebuconazole | - |
Sus scrofa | |
1.14.14.32 | tetrabromobisphenol A | - |
Sus scrofa |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.14.32 | microsome | - |
Sus scrofa | - |
- |
1.14.14.32 | microsome | - |
Homo sapiens | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.32 | 7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2 | Sus scrofa | - |
7-dehydro-dehydroepiandrosterone + acetate + A + H2O | - |
? | |
1.14.14.32 | 7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2 | Homo sapiens | - |
7-dehydro-dehydroepiandrosterone + acetate + A + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.32 | Homo sapiens | P05093 | - |
- |
1.14.14.32 | Sus scrofa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.32 | adrenal cortex | - |
Sus scrofa | - |
1.14.14.32 | H295R cell | human adrenocorticocarcinoma cell line | Homo sapiens | - |
1.14.14.32 | placenta | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.14.14.32 | 0.0000073 | - |
adrenal cortex microsomes, pH and temperature not specified in the publication | Sus scrofa |
1.14.14.32 | 0.0000375 | - |
H295R cell assay, pH and temperature not specified in the publication | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.32 | 7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2 | - |
Sus scrofa | 7-dehydro-dehydroepiandrosterone + acetate + A + H2O | - |
? | |
1.14.14.32 | 7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2 | - |
Homo sapiens | 7-dehydro-dehydroepiandrosterone + acetate + A + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.32 | CYP17 | - |
Sus scrofa |
1.14.14.32 | CYP17 | - |
Homo sapiens |
1.14.14.32 | cytochrome P450 17 | - |
Sus scrofa |
1.14.14.32 | cytochrome P450 17 | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.14.14.32 | 0.000039 | - |
adrenal cortex microsomes, pH and temperature not specified in the publication | Sus scrofa | SU10603 | |
1.14.14.32 | 0.000051 | - |
adrenal cortex microsomes, pH and temperature not specified in the publication | Sus scrofa | ketoconazole | |
1.14.14.32 | 0.000061 | - |
H295R cell assay, pH and temperature not specified in the publication | Homo sapiens | SU10603 | |
1.14.14.32 | 0.00007 | - |
H295R cell assay, pH and temperature not specified in the publication | Homo sapiens | ketoconazole | |
1.14.14.32 | 0.000084 | - |
H295R cell assay, pH and temperature not specified in the publication | Homo sapiens | dioctyltin chloride | |
1.14.14.32 | 0.00013 | - |
adrenal cortex microsomes, pH and temperature not specified in the publication | Sus scrofa | flusilazole | |
1.14.14.32 | 0.00014 | - |
adrenal cortex microsomes, pH and temperature not specified in the publication | Sus scrofa | tebuconazole | |
1.14.14.32 | 0.014 | - |
adrenal cortex microsomes, pH and temperature not specified in the publication | Sus scrofa | diethylstilbestrol | |
1.14.14.32 | 0.016 | - |
H295R cell assay, pH and temperature not specified in the publication | Homo sapiens | flusilazole | |
1.14.14.32 | 0.02 | 2 | adrenal cortex microsomes, pH and temperature not specified in the publication | Sus scrofa | methylmercury | |
1.14.14.32 | 0.093 | - |
adrenal cortex microsomes, pH and temperature not specified in the publication | Sus scrofa | tetrabromobisphenol A |