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Literature summary extracted from

  • Yeung, J.; Apopa, P.L.; Vesci, J.; Stolla, M.; Rai, G.; Simeonov, A.; Jadhav, A.; Fernandez-Perez, P.; Maloney, D.J.; Boutaud, O.; Holman, T.R.; Holinstat, M.
    12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity (2013), Thromb. Haemost., 110, 569-581.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.31 baicalein 12-LOX inhibition attenuates platelet aggregation Homo sapiens
1.13.11.31 NCTT-956 12-LOX inhibition attenuates platelet aggregation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Homo sapiens
-
-
-
1.13.11.31 Mus musculus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 12-LOX
-
 Mus musculus
1.13.11.31 12-LOX
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.13.11.31 malfunction 12-LOX inhibition attenuates platelet aggregation Homo sapiens
1.13.11.31 malfunction the time to cessation of bleeding in 12-LOX-/- mice is significantly prolonged. Mice deficient in 12-LOX show a significant attenuation of alphaIIbeta3 activation for both agonists compared to wild-type mice Mus musculus
1.13.11.31 physiological function inhibition of 12-LOX activity inhibits platelet aggregation, which is coupled to a significant shift in the ability of the platelet to induce normal integrin activation, dense granule secretion, and platelet adhesion under venous shear Homo sapiens