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Literature summary extracted from

  • Xu, S.; Mueser, T.C.; Marnett, L.J.; Funk, M.O.
    Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis (2012), Structure, 20, 1490-1497.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.31 expressed in Escherichia coli Sus scrofa

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.13.11.31 crystals diffracting to high resolution (1.9 A) are obtained for a complex between the catalytic domain of leukocyte 12-lipoxygenase and the isoform-specific inhibitor, 4-(2-oxapentadeca-4-yne) phenylpropanoic acid (OPP) Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.31 4-(2-oxapentadeca-4-yne) phenylpropanoic acid
-
Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Sus scrofa P16469
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 arachidonic acid + O2
-
Sus scrofa (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 12-lipoxygenase
-
Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.31 25
-
assay at Sus scrofa