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Literature summary extracted from

  • Li, L.; Palencia, A.; Lukk, T.; Li, Z.; Luthey-Schulten, Z.A.; Cusack, S.; Martinis, S.A.; Boniecki, M.T.
    Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens (2013), Proc. Natl. Acad. Sci. USA, 110, 3817-3822.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.1.1.4 hanging drop vapor diffusion method, using 0.1 M bis-Tris (pH 5.5), 0.6 M ammonium acetate, and 20% (w/v) PEG3350 at 4°C Mesomycoplasma mobile

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.4 Zn2+ contains zinc Mycoplasmopsis synoviae
6.1.1.4 Zn2+ contains zinc Mesomycoplasma mobile

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.4 ATP + L-leucine + tRNALeu Mycoplasmopsis synoviae
-
 AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 ATP + L-leucine + tRNALeu Mesomycoplasma mobile
-
 AMP + diphosphate + L-leucyl-tRNALeu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.4 Mesomycoplasma mobile
-
-
-
6.1.1.4 Mycoplasmopsis synoviae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.4 ATP + L-isoleucine + 2'-deoxaadenosine-tRNALeu 2'-deoxyadenosine-tRNA clearly stimulates AMP production in the presence of isoleucine, but not the cognate leucine substrate Mycoplasmopsis synoviae AMP + ?
-
 ?
6.1.1.4 ATP + L-leucine + tRNALeu
-
 Mycoplasmopsis synoviae AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 ATP + L-leucine + tRNALeu
-
 Mesomycoplasma mobile AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 additional information the enzyme maintains weak pre-transfer editing activities Mycoplasmopsis synoviae ?
-
 ?
6.1.1.4 additional information the enzyme maintains weak pretransfer editing activities Mesomycoplasma mobile ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.4 Leucyl-tRNA synthetase
-
 Mycoplasmopsis synoviae
6.1.1.4 Leucyl-tRNA synthetase
-
 Mesomycoplasma mobile
6.1.1.4 LeuRS
-
 Mycoplasmopsis synoviae
6.1.1.4 LeuRS
-
 Mesomycoplasma mobile

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.4 ATP
-
 Mycoplasmopsis synoviae
6.1.1.4 ATP
-
 Mesomycoplasma mobile

General Information

EC Number General Information Comment Organism
6.1.1.4 physiological function the enzyme naturally produces mischarged tRNALeu Mycoplasmopsis synoviae
6.1.1.4 physiological function the enzyme naturally produces mischarged tRNALeu Mesomycoplasma mobile