EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.95 | Homo sapiens | Q96EF0 | isoform MTMR8 | - |
3.1.3.95 | Homo sapiens | Q9Y217 | isoform MTMR6 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.95 | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O | presence of catalytically inactive MTMR9 increases the enzymatic activity of isoform MTMR6 toward 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate by over 30fold | Homo sapiens | 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate | - |
? | |
3.1.3.95 | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O | presence of catalytically inactive MTMR9 increases the enzymatic activity of isoform MTMR8 toward 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate by 1.4fold | Homo sapiens | 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate | - |
? | |
3.1.3.95 | 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O | presence of catalytically inactive MTMR9 increases the enzymatic activity of isoform MTMR6 toward 1-phosphatidyl-1D-myo-inositol 3-phosphate by 2fold | Homo sapiens | 1-phosphatidyl-1D-myo-inositol + phosphate | - |
? | |
3.1.3.95 | 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O | presence of catalytically inactive MTMR9 increases the enzymatic activity of isoform MTMR8 toward 1-phosphatidyl-1D-myo-inositol 3-phosphate by 4fold | Homo sapiens | 1-phosphatidyl-1D-myo-inositol + phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.95 | MTMR6 | - |
Homo sapiens |
3.1.3.95 | MTMR8 | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.3.95 | physiological function | complex formation between the active isoform MTMR6 and catalytically inactive MTMR9 increases its catalytic activity and alters its substrate specificity. The MTMR6/MTMR9 complex prefers 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate as substrate. Presence of MTMR9 increases the enzymatic activity of MTMR6 toward 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate by over 30fold, and enhances the activity toward 1-phosphatidyl-1D-myo-inositol 3-phosphate by only 2fold. In cells, the MTMR6/R9 complex significantly increases the cellular levels of 1-phosphatidyl-1D-myo-inositol 3-phosphate, the product of 1-phosphatidyl-1D-myo-inositol 3-phosphate dephosphorylation | Homo sapiens |
3.1.3.95 | physiological function | complex formation between the active isoform MTMR6 and catalytically inactive MTMR9 increases its catalytic activity and alters its substrate specificity. The MTMR6/MTMR9 complex prefers 1-phosphatidyl-1D-myo-inositol 3-phosphate as substrate. Presence of MTMR9 increases the enzymatic activity of MTMR8 toward 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate by 1.4fold, and enhances the activity toward 1-phosphatidyl-1D-myo-inositol 3-phosphate by 4fold. In cells, the MTMR8/R9 complex reduces the cellular levels of 1-phosphatidyl-1D-myo-inositol 3-phosphate | Homo sapiens |