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Literature summary extracted from

  • Shih, D.F.; Hsiao, C.D.; Min, M.Y.; Lai, W.S.; Yang, C.W.; Lee, W.T.; Lee, S.J.
    Aromatic L-amino acid decarboxylase (AADC) is crucial for brain development and motor functions (2013), PLoS ONE, 8, e71741.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.1.1.28 analysis loss of dopa decarboxylase appears to result in similar phenotypes as those of aromatic L-amino acid decarboxylase deficiency, thus zebrafish could be a good model for investigating pathogenetic mechanisms of aromatic L-amino acid decarboxylase deficiency in children Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.28 Danio rerio Q7SZR0
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.28 diencephalon diencephalic catecholaminergic cluster and locus caeruleus of 36-h post-fertilization zebrafish embryos Danio rerio
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4.1.1.28 embryo epiphysis, locus caeruleus, diencephalic catecholaminergic clusters, and raphe nuclei of 36-h post-fertilization zebrafish embryos Danio rerio
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4.1.1.28 epiphysis of 36-h post-fertilization zebrafish embryos Danio rerio
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4.1.1.28 raphe nucleus of 36-h post-fertilization zebrafish embryos Danio rerio
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Synonyms

EC Number Synonyms Comment Organism
4.1.1.28 DDC
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 Danio rerio

General Information

EC Number General Information Comment Organism
4.1.1.28 physiological function inhibition of dopa dearboxylase by inhibitor NSD-1015 or anti-sense morpholino oligonucleotides reduces brain volume and body length. Oligonucleotide-treated emryos display brain cell apoptosis and loss of dipencephalic catecholaminergic cluster neurons as well as seizure-like activity in a dose-dependent manner. Treated embroys have less sensitive touch response and impaired swimming activity that can be rescued by injection of plasmids carrying the dopa decarboxylase gene. In addition, eye movement is significantly impaired in treated embryos Danio rerio