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Literature summary extracted from

  • Sharma, R.; Florea, M.; Nau, W.M.; Swaminathan, K.
    Validation of drug-like inhibitors against Mycobacterium tuberculosis L-aspartate alpha-decarboxylase using nuclear magnetic resonance (1H NMR) (2012), PLoS ONE, 7, e45947.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.11 expression of His6tagged enzyme in Escherichia coli Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.11 (2S,3R,4S,5S)-2,3,4,6-tetrahydroxy-5-mercaptohexanal ZINC03871163 Mycobacterium tuberculosis
4.1.1.11 2,4-dihydroxypyrimidine-5-carboxylate ZINC00901606, moderate inhibition Mycobacterium tuberculosis
4.1.1.11 D-tagatose ZINC03830878, weak inhibition Mycobacterium tuberculosis
4.1.1.11 D-Tartrate ZINC00895296, strong inhibition Mycobacterium tuberculosis
4.1.1.11 DL-threo-beta-hydroxyaspartate strong inhibition Mycobacterium tuberculosis
4.1.1.11 L-cysteic acid strong inhibition Mycobacterium tuberculosis
4.1.1.11 L-glutamate strong inhibition Mycobacterium tuberculosis
4.1.1.11 L-serine weak inhibition Mycobacterium tuberculosis
4.1.1.11 L-Tartrate ZINC00895301, strong inhibition Mycobacterium tuberculosis
4.1.1.11 additional information no inhibition by D-serine, (4S)-1,3-thiazolidin-3-ium-4-carboxylate, alpha-D-arabinopyranose, and 1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one Mycobacterium tuberculosis
4.1.1.11 oxaloacetate very strong inhibition Mycobacterium tuberculosis
4.1.1.11 succinate moderate inhibition Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.11 L-aspartate Mycobacterium tuberculosis
-
 beta-alanine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.11 Mycobacterium tuberculosis
-
 gene panD
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.11 recombinant His6-tagged enzyme from Escherichia coli by nickel affinity chromatography, gel filtration, and dialysis Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.11 L-aspartate
-
 Mycobacterium tuberculosis beta-alanine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.11 L-Aspartate alpha-decarboxylase
-
 Mycobacterium tuberculosis
4.1.1.11 MtbADC
-
 Mycobacterium tuberculosis