Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sharma, R.; Kothapalli, R.; Van Dongen, A.M.; Swaminathan, K.
    Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate alpha-decarboxylase (2012), PLoS ONE, 7, e33521.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.1.1.11 drug development the enzyme is a good drug target Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.11 (2S,3R,4S,5S)-2,3,4,6-tetrahydroxy-5-mercaptohexanal ZINC03871163 Mycobacterium tuberculosis
4.1.1.11 (2S,3S,4R,5R)tetrahydro-2H-pyran2,3,4,5-tetraol ZINC03606295 Mycobacterium tuberculosis
4.1.1.11 (2S,3S,4R,5S)2,5bis(hydroxymethyl)tetrahydrofuran-2,3,4-triol ZINC03830875 Mycobacterium tuberculosis
4.1.1.11 (2S,3S,4S,5R)-2(hydroxymethyl) tetrahydro-2H-pyran-2,3,4,5-tetraol ZINC03830878 Mycobacterium tuberculosis
4.1.1.11 (S)-5-acetoxy-4-methylpentanoate ZINC02036492 Mycobacterium tuberculosis
4.1.1.11 (S)-thiazolidin-3-ium-4-carboxylate ZINC00967474 Mycobacterium tuberculosis
4.1.1.11 1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one ZINC05177572 Mycobacterium tuberculosis
4.1.1.11 3-amino-4-(propylamino)cyclobutane-1 2-dione LIGAND10436 Mycobacterium tuberculosis
4.1.1.11 additional information potential inhibitor molecule docking using the enzyme's crystal structure, overview Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.11 L-aspartate Mycobacterium tuberculosis
-
 beta-alanine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.11 Mycobacterium tuberculosis
-
 gene panD
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.11 L-aspartate
-
 Mycobacterium tuberculosis beta-alanine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.11 L-Aspartate alpha-decarboxylase
-
 Mycobacterium tuberculosis
4.1.1.11 MtbADC
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.11 pyruvoyl cofactor dependent on Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
4.1.1.11 evolution L-aspartate alpha-decarboxylase belongs to a class of pyruvoyl dependent enzymes Mycobacterium tuberculosis
4.1.1.11 metabolism L-aspartate alpha-decarboxylase catalyzes the conversion of aspartate to beta-alanine in the pantothenate pathway, which is critical for the growth of Mycobacterium tuberculosis Mycobacterium tuberculosis
4.1.1.11 additional information the enzyme active site is formed by the interface of a dimer, with relatively small volume. This cleft can support only molecules of relatively small size Mycobacterium tuberculosis