Literature summary extracted from

Wang, S.; Yang, S.; An, B.; Wang, S.; Yin, Y.; Lu, Y.; Xu, Y.; Hao, D.
Molecular dynamics analysis reveals structural insights into mechanism of nicotine N-demethylation catalyzed by tobacco cytochrome P450 mono-oxygenase (2011), PLoS ONE, 6, e23342.

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.14.14.B11	C330W	inactive	Nicotiana tabacum

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.14.B11	nicotine + O2 + [reduced NADPH-hemoprotein reductase] + O2	Nicotiana tabacum	-	nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.B11	Nicotiana tabacum	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.14.B11	leaf	-	Nicotiana tabacum	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.B11	nicotine + O2 + [reduced NADPH-hemoprotein reductase] + O2	-	Nicotiana tabacum	nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.14.B11	CYP82E4	-	Nicotiana tabacum
1.14.14.B11	NND	-	Nicotiana tabacum

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.14.14.B11	cytochrome P450	-	Nicotiana tabacum
1.14.14.B11	NADPH	-	Nicotiana tabacum

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Release 2023.1 (January 2023)