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Literature summary extracted from

  • Savidge, B.; Weiss, J.D.; Wong, Y.H.; Lassner, M.W.; Mitsky, T.A.; Shewmaker, C.K.; Post-Beittenmiller, D.; Valentin, H.E.
    Isolation and characterization of homogentisate phytyltransferase genes from Synechocystis sp. PCC 6803 and Arabidopsis (2002), Plant Physiol., 129, 321-332.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.115 membrane
-
 Arabidopsis thaliana 16020
-
2.5.1.115 membrane
-
 Synechocystis sp. 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.115 Arabidopsis thaliana Q8VWJ1
-
-
2.5.1.115 Synechocystis sp. P73726
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.115 phytyl diphosphate + homogentisate
-
 Arabidopsis thaliana diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
-
 ?
2.5.1.115 phytyl diphosphate + homogentisate
-
 Synechocystis sp. diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO2
-
 ?

General Information

EC Number General Information Comment Organism
2.5.1.115 physiological function a null mutant obtained by insertional inactivation does not accumulate tocopherols, and is rescued by the Arabidopsis HPT1 ortholog. The membrane fraction of wild-type Synechocystis sp. PCC 6803 is capable of catalyzing the phytylation of homogentisate, whereas the membrane fraction from the slr1736 null mutant is not Synechocystis sp.
2.5.1.115 physiological function a Synechocystis sp. PCC 6803 homogentisate phytyltransferase null mutant is rescued by the Arabidopsis HPT1 ortholog. Antisense expression of HPT1 in Arabidopsis results in reduced seed tocopherol levels, whereas seed-specific sense expression results in increased seed tocopherol levels Arabidopsis thaliana