EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.3.1 | 3-nitropropionic acid | - |
Pseudomonas aeruginosa | |
4.1.3.1 | Itaconic acid | - |
Pseudomonas aeruginosa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.3.1 | isocitrate | Pseudomonas aeruginosa | - |
succinate + glyoxylate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.3.1 | Pseudomonas aeruginosa | - |
gene aceA | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.1.3.1 | additional information | high enzyme expression in cystic fibrosis samples | Pseudomonas aeruginosa | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.3.1 | isocitrate | - |
Pseudomonas aeruginosa | succinate + glyoxylate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.3.1 | AceA | - |
Pseudomonas aeruginosa |
4.1.3.1 | ICL | - |
Pseudomonas aeruginosa |
EC Number | General Information | Comment | Organism |
---|---|---|---|
4.1.3.1 | malfunction | an aceA mutant displays enhanced biofilm formation during anaerobic growth. Expression of PcrV, of PopN (a regulator of the T3SS translocation process), ExoS (a T3 effector protein), and ExsD (a T3S regulator) is greatly reduced in the aceA mutant. Expression of aceA from a plasmid in trans can restore PcrV expression and ICL activity in the aceA mutant | Pseudomonas aeruginosa |
4.1.3.1 | metabolism | the enzyme is important in the glyoxylate shunt pathway, which is strongly induced in Pseudomonas aeruginosa during anaerobic growth and during growth on C2-sources, such as acetate or fatty acids, as the sole carbon source, overview | Pseudomonas aeruginosa |
4.1.3.1 | physiological function | the enzyme regulates the type III secretion system, T3SS, overview. Expression of the T3SS in oxygen-limited growth conditions is strongly dependent on the glyoxylate shunt enzyme, isocitrate lyase, which probably affects the RetS/LadS signalling pathways. ICL-dependent regulation of the T3SS does not alter the expression level of the master transcriptional regulator, ExsA, but affects expression of the T3 structural proteins, effectors and regulators, ExsC, ExsD and ExsE | Pseudomonas aeruginosa |