Literature summary extracted from

Just, I.; Selzer, J.; Wilm, M.; von Eichel-Streiber, C.; Mann, M.; Aktories, K.
Glucosylation of Rho proteins by Clostridium difficile toxin B (1995), Nature, 375, 500-503.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.B62	Clostridioides difficile	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.1.B62	UDP-alpha-D-glucose + RhoA	-	Clostridioides difficile	UDP + D-glucosyl-RhoA	toxin B catalyses the incorporation of up to one mole of glucose per mole of RhoA at the amino acid threonine at position 37. UDP-glucose selectively serves as cosubstrate for the monoglucosylation reaction	?

General Information

EC Number	General Information	Comment	Organism
2.4.1.B62	physiological function	microinjection of RhoA previously glucosylated by toxin B into monolayer cells causes disaggregation of actin filaments, indicating a dominant-negative activity of glucosylated RhoA	Clostridioides difficile

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Release 2023.1 (January 2023)