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Literature summary extracted from

  • Keller, T.L.; Zocco, D.; Sundrud, M.S.; Hendrick, M.; Edenius, M.; Yum, J.; Kim, Y.J.; Lee, H.K.; Cortese, J.F.; Wirth, D.F.; Dignam, J.D.; Rao, A.; Yeo, C.Y.; Mazitschek, R.; Whitman, M.
    Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase (2012), Nat. Chem. Biol., 8, 311-317.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.1.1.15 expressed in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.15 febrifugine
-
 Homo sapiens
6.1.1.15 halofuginone competitive inhibitor Homo sapiens
6.1.1.15 additional information MAZ1310 has no inhibitory effect on enzyme activity Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.15 ATP + L-proline + tRNAPro Homo sapiens
-
 AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.15 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.1.1.15
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.15 ATP + L-proline + tRNAPro
-
 Homo sapiens AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.15 EPRS
-
 Homo sapiens
6.1.1.15 glutamyl-prolyl tRNA synthetase
-
 Homo sapiens
6.1.1.15 prolyl tRNA synthetase
-
 Homo sapiens
6.1.1.15 ProRS
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.15 ATP
-
 Homo sapiens