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Literature summary extracted from

  • Gaisser, S.; Reather, J.; Wirtz, G.; Kellenberger, L.; Staunton, J.; Leadlay, P.F.
    A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea (2000), Mol. Microbiol., 36, 391-401.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.316 Streptomyces fradiae
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.316 tylactone + dTDP-D-desosaminose
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 Streptomyces fradiae dTDP + 5-O-desosaminyl-tylactone
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 ?

General Information

EC Number General Information Comment Organism
2.4.1.316 physiological function expression of the mycaminosyltransferase TylM2 from Streptomyces fradiae in Saccharopolyspora erythraea SGT2 lacking both eryBV and eryCIII genes encoding the respective glycosyltransferase genes and glycosyltransferase OleG2. Feeding of the resulting strain with the 16-membered aglycone tylactone, the normal TylM2 substrate, leads to formation of a new hybrid glycoside; 5-O-desosaminyl-tylactone Streptomyces fradiae