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Literature summary extracted from
- Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association (2014), Mol. Cell, 53, 562-576.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.4.1 | Caenorhabditis elegans | Q11067 | - |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | PDIA6 | - |
Caenorhabditis elegans |
| 5.3.4.1 | protein disulfide isomerase A6 | - |
Caenorhabditis elegans |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | malfunction | PDIA6-deficient cells hyperrespond to endoplasmic reticulum stress with sustained autophosphorylation of inositol-requiring enzyme 1alpha and splicing of XBP1 mRNA, resulting in exaggerated upregulation of UPR target genes and increased apoptosis. In vivo, PDIA6-deficient Caenorhabditis elegans exhibits constitutive unfolded protein response and fails to complete larval development | Caenorhabditis elegans |
| 5.3.4.1 | physiological function | isoform PDIA6 limits the duration of inositol-requiring enzyme 1alpha (IRE1alpha) activity by direct binding to cysteine 148 in the lumenal domain of the sensor, which is oxidized when IRE1 is activated | Caenorhabditis elegans |
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