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Literature summary extracted from
- Alanine racemase mutants of Mycobacterium tuberculosis require D-alanine for growth and are defective for survival in macrophages and mice (2012), Microbiology, 158, 319-327.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 5.1.1.1 | pharmacology | Alr of Mycobacterium tuberculosis is a valid drug target and inhibition of Alr alone results in loss of viability in vitro and in vivo | Mycobacterium tuberculosis |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.1 | D-cycloserine | specific inhibition is reversible by D-alanine in the growth medium | Mycobacterium tuberculosis |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.1.1 | L-alanine | Mycobacterium tuberculosis | - |
D-alanine | - |
r | |
| 5.1.1.1 | L-alanine | Mycobacterium tuberculosis H37Rv | - |
D-alanine | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.1.1.1 | Mycobacterium tuberculosis | P9WQA9 | - |
- |
| 5.1.1.1 | Mycobacterium tuberculosis H37Rv | P9WQA9 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.1.1 | L-alanine | - |
Mycobacterium tuberculosis | D-alanine | - |
r | |
| 5.1.1.1 | L-alanine | - |
Mycobacterium tuberculosis H37Rv | D-alanine | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.1.1.1 | ALR | - |
Mycobacterium tuberculosis |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.1 | pyridoxal 5'-phosphate | dependent on | Mycobacterium tuberculosis | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.1.1.1 | malfunction | depletion of D-alanine results in rapid loss of viability. The alr mutant is defective for growth in macrophages | Mycobacterium tuberculosis |
| 5.1.1.1 | physiological function | the enzyme is essential for the organism, it is not possible to generate an alr knockout mutant in the absence of a complementing gene copy or D-alanine in the growth medium | Mycobacterium tuberculosis |
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