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Literature summary extracted from

  • Cao, F.; Gamble, A.; Kim, H.; Onagi, H.; Gresser, M.; Kerr, J.; Easton, C.
    Potent and selective inhibitors of human peptidylglycine alpha-amidating monooxygenase (2011), MedChemComm, 2, 760-763.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.3 (decanoylsulfanyl)acetic acid
-
 Homo sapiens
1.14.17.3 (dodecanoyloxy)acetic acid
-
 Homo sapiens
1.14.17.3 decanoyloxyacetic acid
-
 Homo sapiens
1.14.17.3 [(phenylacetyl)oxy]acetic acid
-
 Homo sapiens
1.14.17.3 [(phenylacetyl)sulfanyl]acetic acid
-
 Homo sapiens
1.14.17.3 [[(2S)-2-(acetylamino)-3-phenylpropanoyl]oxy]acetic acid
-
 Homo sapiens
1.14.17.3 [[(2S)-2-(acetylamino)-3-phenylpropanoyl]sulfanyl]acetic acid
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.3 0.015
-
 N-acetyl-L-phenylalanylglycine pH and temperature not specified in the publication Homo sapiens
1.14.17.3 0.2
-
 N-decanoylglycine pH and temperature not specified in the publication Homo sapiens
1.14.17.3 0.33
-
 N-(Phenylacetyl)glycine pH and temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.17.3 peptidylglycine + ascorbate + O2 Homo sapiens
-
 peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.3 NCI-H889 cell
-
 Homo sapiens
-
1.14.17.3 small cell lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.3 N-(phenylacetyl)glycine + ascorbate + O2
-
 Homo sapiens ? + dehydroascorbate + H2O
-
 ?
1.14.17.3 N-acetyl-L-phenylalanylglycine + ascorbate + O2
-
 Homo sapiens ? + dehydroascorbate + H2O
-
 ?
1.14.17.3 N-decanoylglycine + ascorbate + O2
-
 Homo sapiens ?
-
 ?
1.14.17.3 peptidylglycine + ascorbate + O2
-
 Homo sapiens peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.3 PAM
-
 Homo sapiens
1.14.17.3 peptidylglycine alpha-amidating monooxygenase
-
 Homo sapiens
1.14.17.3 peptidylglycine alpha-hydroxylating monooxygenase subunit of bifunctional peptidylglycine alpha-amidating monooxygenase (PAM) Homo sapiens
1.14.17.3 PHM
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.17.3 ascorbate
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.17.3 0.00005
-
 pH and temperature not specified in the publication Homo sapiens decanoyloxyacetic acid
1.14.17.3 0.00006
-
 pH and temperature not specified in the publication Homo sapiens (dodecanoyloxy)acetic acid
1.14.17.3 0.002
-
 pH and temperature not specified in the publication Homo sapiens [(phenylacetyl)oxy]acetic acid
1.14.17.3 0.006
-
 pH and temperature not specified in the publication Homo sapiens [[(2S)-2-(acetylamino)-3-phenylpropanoyl]oxy]acetic acid
1.14.17.3 0.007
-
 pH and temperature not specified in the publication Homo sapiens (decanoylsulfanyl)acetic acid
1.14.17.3 0.045
-
 pH and temperature not specified in the publication Homo sapiens [(phenylacetyl)sulfanyl]acetic acid
1.14.17.3 0.045
-
 pH and temperature not specified in the publication Homo sapiens [[(2S)-2-(acetylamino)-3-phenylpropanoyl]sulfanyl]acetic acid