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Literature summary extracted from

  • Csiszovszki, Z.; Krishna, S.; Orosz, L.; Adhya, S.; Semsey, S.
    Structure and function of the D-galactose network in enterobacteria (2011), mBio, 2, 00053-00011.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.1.3.3 gene galM, DNA and amino acid sequence determination and analysis, sequence comparisons, transcription of the galETK operon is initiated from a single promoter, recombinant expression of His6-tagged enzyme in Escherichia coli strain MG1655 Yersinia pestis

Protein Variants

EC Number Protein Variants Comment Organism
5.1.3.3 additional information galactose mutarotase (galM) gene is inactivated by a single-base-pair deletion, activity of the galM gene can be restored by different single-base-pair insertions Yersinia pestis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.3 alpha-D-galactose Yersinia pestis
-
 beta-D-galactose
-
 r
5.1.3.3 alpha-D-galactose Yersinia pestis KIM D27
-
 beta-D-galactose
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.1.3.3 Yersinia pestis
-
 gene galM
-
5.1.3.3 Yersinia pestis KIM D27
-
 gene galM
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.1.3.3 recombinant His6-tagged enzyme from Escherichia coli strain MG1655 Yersinia pestis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.3.3 alpha-D-galactose
-
 Yersinia pestis beta-D-galactose
-
 r
5.1.3.3 alpha-D-galactose
-
 Yersinia pestis KIM D27 beta-D-galactose
-
 r

Synonyms

EC Number Synonyms Comment Organism
5.1.3.3 galactose mutarotase
-
 Yersinia pestis
5.1.3.3 GalM
-
 Yersinia pestis

General Information

EC Number General Information Comment Organism
5.1.3.3 evolution the galM pseudogene has not been deleted during the evolution of Yersinia pestis to become a vector-transmitted systemic pathogen because its reactivation may be beneficial in certain environments. The galactose mutarotase (galM) gene of Yersinia pestis can be converted to a pseudogene by a single-base-pair deletion, overview Yersinia pestis
5.1.3.3 metabolism GalM function and regulation in the galactose network, overview Yersinia pestis
5.1.3.3 physiological function the two anomers of D-galactose are used for different purposes, alpha-D-galactose as a carbon source and beta-D-galactose for induction of UDP-galactose synthesis for biosynthetic glycosylation Yersinia pestis