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Literature summary extracted from

  • Luo, W.; Hershberger, P.A.; Trump, D.L.; Johnson, C.S.
    24-Hydroxylase in cancer: impact on vitamin D-based anticancer therapeutics (2013), J. Steroid Biochem. Mol. Biol., 136, 252-257.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.14.15.16 medicine elevated tumor CYP24A1 expression is associated with a poor prognosis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.16 2-(4-hydroxybenzyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one
-
 Homo sapiens
1.14.15.16 CTA018
-
 Homo sapiens
1.14.15.16 CTA091
-
 Homo sapiens
1.14.15.16 ketoconazole
-
 Homo sapiens
1.14.15.16 liarozole
-
 Homo sapiens
1.14.15.16 VID400 i.e. (R)-N-(2-(1H-imidazol-1-yl)-2-phenylethyl)-4-chlorobiphenyl-4-carboxamide, exhibits strong and selective CYP24A1 inhibitory activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.16 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.16 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 Homo sapiens
-
 1alpha,24,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 25-hydroxyvitamin D3 + NADPH + H+ + O2 Homo sapiens
-
 24,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.16 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.16 kidney highest activity in kidney Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.16 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 1alpha,24,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 25-hydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 24,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.16 CYP24A1
-
 Homo sapiens
1.14.15.16 vitamin D 24-hydroxylase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.16 NADPH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.15.16 0.000015
-
 pH and temperature not specified in the publication Homo sapiens VID400

Expression

EC Number Organism Comment Expression
1.14.15.16 Homo sapiens enzyme expression is upregulated in cancer cells up