Any feedback?
Literature summary extracted from
- Combined QM/MM investigation on the light-driven electron-induced repair of the (6-4) thymine dimer catalyzed by DNA photolyase (2013), J. Phys. Chem. B, 117, 10071-10079.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.99.13 | Drosophila melanogaster | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 4.1.99.13 | (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA) | repair photocycle of (6-4) thymine photoproduct by (6-4) photolyase, which involves light absorption by the 8-HDF cofactor and transfer of the excitation energy to the FADH-. Intermolecular Coulombic decay resulting in an electron transfer from FADH? to the dimer initiating the splitting process, mechanism, detailed overview. The mechanism requires the C5-OH transfer from C5 of the 5' thymine to the C4' of the 3' thymine followed by H transfer to the N3' of the 3' thymine. Of two conserved histidine residues, only His365 is protonated | Drosophila melanogaster |
aSynonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.99.13 | (6-4) photolyase | - |
Drosophila melanogaster |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 4.1.99.13 | additional information | quantum mechanical/molecular mechanics simulations using X-ray structure of the enzyme-DNA complex, overview | Drosophila melanogaster |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
