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Literature summary extracted from

  • Fernandez, I.; Harlow, L.; Zang, Y.; Liu-Bryan, R.; Ridgway, W.M.; Clemens, P.R.; Ascherman, D.P.
    Functional redundancy of MyD88-dependent signaling pathways in a murine model of histidyl-transfer RNA synthetase-induced myositis (2013), J. Immunol., 191, 1865-1872.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.21 ATP + L-histidine + tRNAHis Homo sapiens
-
 AMP + diphosphate + L-histidyl-tRNAHis
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.21 ATP + L-histidine + tRNAHis
-
 Homo sapiens AMP + diphosphate + L-histidyl-tRNAHis
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.21 histidyl-transfer RNA synthetase
-
 Homo sapiens
6.1.1.21 Histidyl-tRNA synthetase
-
 Homo sapiens
6.1.1.21 HRS
-
 Homo sapiens
6.1.1.21 Jo-1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.21 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
6.1.1.21 physiological function the enzyme induces muscle inflammation in B6.TLR2 and B6.TLR4 knockout mice. The enzyme induces interleukin 8 production in toll-like-receptor-transfected HEK-293 cells Homo sapiens