Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Goncalves, C.; Decre, D.; Barbut, F.; Burghoffer, B.; Petit, J.
    Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile (2004), J. Clin. Microbiol., 42, 1933-1939.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.31 Clostridioides difficile
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.31 actin + NAD+
-
Clostridioides difficile ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.31 binary toxin
-
Clostridioides difficile
2.4.2.31 CDT
-
Clostridioides difficile

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.31 7.5
-
assay at Clostridioides difficile

General Information

EC Number General Information Comment Organism
2.4.2.31 physiological function enzyme is an actin-specific ADP-ribosyltransferase, called binary toxin CDT, present in about 6% of strains isolated from patients with suspected Peptoclostridium difficile-associated diarrhea or colitis. All binary toxin-positive strains tested also produce toxins TcdB and/or TcdA. However, they have significant changes in the tcdA and tcdB genes and belong to variant toxinotypes III, IV, V, VII, IX, and XIII Clostridioides difficile