Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Epis, M.R.; Giles, K.M.; Kalinowski, F.C.; Barker, A.; Cohen, R.J.; Leedman, P.J.
    Regulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cells (2012), J. Biol. Chem., 287, 35251-35259.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.99.29 gene dohh, quantitative expression analysis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.29 mimosine synergistic growth inhibition with the combination of miR-331-3p and miR-642-5p and mimosine Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.29 [eIF5A]-deoxyhypusine + AH2 + O2 Homo sapiens
-
 [eIF5A]-hypusine + A + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.29 Homo sapiens Q9BU89 gene dohh, substrain PEXT-1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.29 22Rv-1 cell
-
 Homo sapiens
-
1.14.99.29 DU-145 cell
-
 Homo sapiens
-
1.14.99.29 LNCaP cell
-
 Homo sapiens
-
1.14.99.29 LNCAP-C4-2B cell
-
 Homo sapiens
-
1.14.99.29 PC-3 cell
-
 Homo sapiens
-
1.14.99.29 prostate cancer cell
-
 Homo sapiens
-
1.14.99.29 prostate gland epithelium
-
 Homo sapiens
-
1.14.99.29 RWPE-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.29 [eIF5A]-deoxyhypusine + AH2 + O2
-
 Homo sapiens [eIF5A]-hypusine + A + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.29 deoxyhypusine hydroxylase
-
 Homo sapiens
1.14.99.29 DOHH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.99.29 Homo sapiens transient overexpression of micro-RNA miR-331-3p and/or miR-642-5p in DU-145 prostate cancer cells reduces DOHH mRNA and protein expression and inhibits cell proliferation down

General Information

EC Number General Information Comment Organism
1.14.99.29 physiological function the enzyme catalyzes the activation of eukaryotic translation initiation factor, eIF5A, a protein essential for cell growth. Expression of DOHH is regulated by micro-RNAs miR-331-3p and miR-642-5p in prostate cancer cells, overview. Transient overexpression of miR-331-3p and/or miR-642-5p in DU-145 prostate cancer cells reduces DOHH mRNA and protein expression and inhibits cell proliferation Homo sapiens