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Literature summary extracted from

  • Pescatore, L.A.; Bonatto, D.; Forti, F.L.; Sadok, A.; Kovacic, H.; Laurindo, F.R.
    Protein disulfide isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration, Nox1 NADPH oxidase expression, and RhoGTPase activation (2012), J. Biol. Chem., 287, 29290-29300.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.4.1 Insulin-(SS) + GSH Oryctolagus cuniculus
-
 Insulin-(SH)2 + GSSG
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.4.1 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.4.1 vascular smooth muscle cell
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.4.1 Insulin-(SS) + GSH
-
 Oryctolagus cuniculus Insulin-(SH)2 + GSSG
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.4.1 PDI
-
 Oryctolagus cuniculus
5.3.4.1 protein disulfide isomerase
-
 Oryctolagus cuniculus

General Information

EC Number General Information Comment Organism
5.3.4.1 malfunction enzyme silencing decreases Nox1 expression and reactive oxygen species production as well as platelet-derived growth factor-induced Rac1 and RhoA activities Oryctolagus cuniculus
5.3.4.1 physiological function protein disulfide isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration, Nox1 NADPH oxidase expression, and Rho-GTPase activation Oryctolagus cuniculus