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Literature summary extracted from

  • de la Paz Santangelo, M.; Gest, P.M.; Guerin, M.E.; Coincon, M.; Pham, H.; Ryan, G.; Puckett, S.E.; Spencer, J.S.; Gonzalez-Juarrero, M.; Daher, R.; Lenaerts, A.J.; Schnappinger, D.; Therisod, M.; Ehrt, S.; Sygusch, J.; Jackson, M.
    Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli (2011), J. Biol. Chem., 286, 40219-40231.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.2.13 native form and in complex with a hydroxamate substrate analog, to 2.35- and 1.9 A resolution, respectively. Inhibitor attachment has no effect on the plasminogen binding activity of the enzyme, it competes with the natural substrate, fructose 1,6-bisphosphate, and substantiates a reaction mechanism associated with metallodependent aldolases involving recruitment of the catalytic zinc ion by the substrate upon active site binding Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.2.13 N-(4-hydroxybutyl)-glycolohydroxamic acid bisphosphate inhibitor attachment has no effect on the plasminogen binding activity of the enzyme but competes with the natural substrate, fructose 1,6-bisphosphate, and substantiates a reaction mechanism associated with metallodependent aldolases involving recruitment of the catalytic zinc ion by the substrate upon active site binding Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.2.13 cell surface
-
 Mycobacterium tuberculosis 9986
-

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.13 Mycobacterium tuberculosis P9WQA3
-
-

Expression

EC Number Organism Comment Expression
4.1.2.13 Mycobacterium tuberculosis protein is produced under various axenic growth conditions including oxygen depletion and hence by non-replicating bacilli, and also in vivo in the lungs of infected guinea pigs and mice. Enzyme binds human plasmin(ogen) and protects bound plasmin from regulation by alpha2-antiplasmin additional information

General Information

EC Number General Information Comment Organism
4.1.2.13 physiological function gene product is required for the growth of Mycobacterium tuberculosis on gluconeogenetic substrates and in glucose-containing medium Mycobacterium tuberculosis