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Literature summary extracted from

  • Ikezawa, N.; Goepfert, J.C.; Nguyen, D.T.; Kim, S.U.; OMaille, P.E.; Spring, O.; Ro, D.K.
    Lettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio- and stereoselective hydroxylations in sesquiterpene lactone metabolism (2011), J. Biol. Chem., 286, 21601-21611.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.150 expressed in Saccharomyces cerevisiae strain EPY300 Helianthus annuus
1.14.14.150 expressed in Saccharomyces cerevisiae strain EPY300 Lactuca sativa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.150 germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 Helianthus annuus
-
 (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.150 germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 Lactuca sativa
-
 (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.150 Helianthus annuus
-
 cultivar HA300
-
1.14.14.150 Lactuca sativa F8S1I0 cultivar Mariska
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.150 glandular trichome
-
 Helianthus annuus
-
1.14.14.150 glandular trichome
-
 Lactuca sativa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.150 germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2
-
 Helianthus annuus (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.150 germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2
-
 Lactuca sativa (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.150 COS
-
 Helianthus annuus
1.14.14.150 COS
-
 Lactuca sativa
1.14.14.150 CYP71BL1
-
 Helianthus annuus
1.14.14.150 CYP71BL2
-
 Lactuca sativa

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.150 cytochrome P450
-
 Helianthus annuus
1.14.14.150 cytochrome P450
-
 Lactuca sativa