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Literature summary extracted from

  • Sandoval-Calderon, M.; Geiger, O.; Guan, Z.; Barona-Gomez. F.; Sohlenkamp, C.
    A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria (2009), J. Biol. Chem., 284, 17383-17390.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.41 expression of Sco1389 in a cardiolipin-deficient Rhizobium etli mutant Streptomyces coelicolor

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.41 EDTA 20 mM, loss of activity Streptomyces coelicolor

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.41 Co2+ the enzyme is dependent on the presence of bivalent cations. The largest activity is found with Co2+, whereas Mn2+ supports a lower activity. No detectable cardiolipin synthase activity when using Ni2+, Ca2+, or Mg2+ Streptomyces coelicolor
2.7.8.41 Mn2+ the enzyme is dependent on the presence of bivalent cations. The largest activity is found with Co2+, whereas Mn2+ supports a lower activity. No detectable cardiolipin synthase activity when using Ni2+, Ca2+, or Mg2+ Streptomyces coelicolor

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol Streptomyces coelicolor
-
 a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol Streptomyces coelicolor A3(2)
-
 a cardiolipin + CMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.41 Streptomyces coelicolor Q9KZP3
-
-
2.7.8.41 Streptomyces coelicolor A3(2) Q9KZP3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol
-
 Streptomyces coelicolor a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol
-
 Streptomyces coelicolor A3(2) a cardiolipin + CMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.41 Sco1389
-
 Streptomyces coelicolor

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.41 7.5
-
-
 Streptomyces coelicolor

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.8.41 6.5 8.5 pH 6.5: aboput 40% of maximal activity, pH 8.5: about 60%& of maximal activity Streptomyces coelicolor