EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.B62 | Clostridioides difficile | P16154 | toxin A | - |
3.1.4.B4 | Clostridioides difficile | P16154 | toxin A | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.B62 | additional information | in the absence of target proteins toxin A acts as hydrolase cleaving UDP-D-glucose to UDP and D-glucose | Clostridioides difficile | ? | - |
? | |
2.4.1.B62 | additional information | UDP-alpha-D-glucose selectively serves as cosubstrate for toxin A-catalyzed modification. The acceptor amino acid of glucosylation is Thr37. Mutation of Thr37 to Ala completely abolishes glucosylation. No substrates: H-Ras, Rab5, and Arf1 | Clostridioides difficile | ? | - |
? | |
2.4.1.B62 | UDP-alpha-D-glucose + Cdc42Hs | - |
Clostridioides difficile | UDP + D-glucosyl-Cdc42Hs | - |
? | |
2.4.1.B62 | UDP-alpha-D-glucose + Rac1 | - |
Clostridioides difficile | UDP + D-glucosyl-Rac1 | - |
? | |
2.4.1.B62 | UDP-alpha-D-glucose + RhoA | - |
Clostridioides difficile | UDP + D-glucosyl-RhoA | - |
? | |
3.1.4.B4 | additional information | no substrates: UDP-galactose, UDP-N-acetylglucosamine | Clostridioides difficile | ? | - |
? | |
3.1.4.B4 | UDP-alpha-D-glucose + H2O | toxin A transfers glucose to small GTPases. In the absence of target proteins, toxin A acts as hydrolase cleaving UDP-D-glucose to UDP and D-glucose | Clostridioides difficile | UDP + D-glucose | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.B4 | UDP-glucose hydrolase | - |
Clostridioides difficile |