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Literature summary extracted from

  • Schlame, M.; Hostetler, K.Y.
    Solubilization, purification, and characterization of cardiolipin synthase from rat liver mitochondria. Demonstration of its phospholipid requirement (1991), J. Biol. Chem., 266, 22398-22403.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.41 0.0016
-
 CDP-dimyristoylglycerol pH 8.5, 37°C, at optimal concentration of phospholipid activators Rattus norvegicus
2.7.8.41 0.045
-
 egg yolk phosphatidylglycerol pH 8.5, 37°C, at optimal concentration of phospholipid activators Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.41 mitochondrion mitochondrial membrane Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.41 Co2+ the enzyme displays an absolute requirement for divalent cations with Co2+ being more efficient than Mg2+ or Mn2+ Rattus norvegicus
2.7.8.41 KCl requires KCl concentration of about 0.4 M Rattus norvegicus
2.7.8.41 Mg2+ the enzyme displays an absolute requirement for divalent cations with Co2+ being more efficient than Mg2+ or Mn2+ Rattus norvegicus
2.7.8.41 Mn2+ the enzyme displays an absolute requirement for divalent cations with Co2+ being more efficient than Mg2+ or Mn2+ Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.8.41 50000
-
 1 * 50000, SDS-PAGE Rattus norvegicus
2.7.8.41 60000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol Rattus norvegicus
-
 a cardiolipin + CMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.41 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.8.41
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.41 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol
-
 Rattus norvegicus a cardiolipin + CMP
-
 ?
2.7.8.41 CDP-dimyristoylglycerol + egg yolk phosphatidylglycerol
-
 Rattus norvegicus cardiolipin + CMP
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.8.41 monomer 1 * 50000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.7.8.41 CL synthase
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.41 8
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.8.41 7.2 8.9 pH 7.2: about 40% of maximal activity, pH 8.9: about 75% of maximal activity Rattus norvegicus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.8.41 Rattus norvegicus isoelectric point 5 4