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Literature summary extracted from

  • Smith, A.C.; Cronan, J.E.
    Dimerization of the bacterial biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity in vivo (2012), J. Bacteriol., 194, 72-78.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
6.3.4.14 E23R the mutant protein has a kcat value about 30% that of the wild type enzyme Escherichia coli
6.3.4.14 F363A the mutant has approximately 84% of the wild type activity Escherichia coli
6.3.4.14 R19E the mutant has about half the activity of the wild type protein Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.14 ATP + biotin-carboxyl-carrier protein + HCO3- Escherichia coli
-
 ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.14 Escherichia coli
-
 substr. MG1655
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.4.14 partial purification Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.14 ATP + biotin-carboxyl-carrier protein + HCO3-
-
 Escherichia coli ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.4.14 dimer
-
 Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
6.3.4.14 AccC
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.4.14 ATP
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
6.3.4.14 physiological function dimerization of the biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity in vivo Escherichia coli