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Literature summary extracted from
- Variable nornicotine enantiomeric composition caused by nicotine demethylase CYP82E4 in tobacco leaf (2012), J. Agric. Food Chem., 60, 11586-11591.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.B11 | (S)-nicotine + [reduced NADPH-hemoprotein reductase] + O2 | Nicotiana tabacum | CYP82E4 selectively demethylates (S)-nicotine | (S)-nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.B11 | Nicotiana tabacum | - |
cultivar TN 90LC | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.B11 | leaf | - |
Nicotiana tabacum | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.B11 | (S)-nicotine + [reduced NADPH-hemoprotein reductase] + O2 | CYP82E4 selectively demethylates (S)-nicotine | Nicotiana tabacum | (S)-nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.B11 | CYP82E4 | - |
Nicotiana tabacum |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.B11 | NADPH | - |
Nicotiana tabacum | |
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Release 2023.1 (January 2023)
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