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Literature summary extracted from

  • Carlson, K.; Overvatn, A.
    Bacteriophage T4 endonucleases II and IV, oppositely affected by dCMP hydroxymethylase activity, have different roles in the degradation and in the RNA polymerase-dependent replication of T4 cytosine-containing DNA (1986), Genetics, 114, 669-685.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.21.9 additional information activity of endonuclease IV is stimulated in the presence of a wild-type dCMP hydroxymethylase Tequatrovirus T4

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.21.8 additional information endonuclease IV activity is almost completely inhibited in the presence of very small amounts of hydroxymethylcytosine in the DNA Tequatrovirus T4

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.21.8 DNA where cytosine is partially or completely replaced by hydroxymethylcytosine + H2O Tequatrovirus T4 DNA where cytosine is partially or completely replaced by hydroxymethylcytosine is degraded in vivo by T4 endonuclease II, EC 3.1.21.8, and endonuclease IV, EC 3.1.21.9 ?
-
 ?
3.1.21.9 DNA where cytosine is partially or completely replaced by hydroxymethylcytosine + H2O Tequatrovirus T4 DNA where cytosine is partially or completely replaced by hydroxymethylcytosine is degraded in vivo by T4 endonuclease II, EC 3.1.21.8, and endonuclease IV, EC 3.1.21.9 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.21.8 Tequatrovirus T4 P07059
-
-
3.1.21.9 Tequatrovirus T4
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.21.8 DNA where cytosine is partially or completely replaced by hydroxymethylcytosine + H2O DNA where cytosine is partially or completely replaced by hydroxymethylcytosine is degraded in vivo by T4 endonuclease II, EC 3.1.21.8, and endonuclease IV, EC 3.1.21.9 Tequatrovirus T4 ?
-
 ?
3.1.21.9 DNA where cytosine is partially or completely replaced by hydroxymethylcytosine + H2O DNA where cytosine is partially or completely replaced by hydroxymethylcytosine is degraded in vivo by T4 endonuclease II, EC 3.1.21.8, and endonuclease IV, EC 3.1.21.9 Tequatrovirus T4 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.21.8 endonuclease IV
-
 Tequatrovirus T4
3.1.21.9 endonuclease IV
-
 Tequatrovirus T4