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Literature summary extracted from

  • Englert, M.; Moses, S.; Hohn, M.; Ling, J.; ODonoghue, P.; Soell, D.
    Aminoacylation of tRNA 2'- or 3'-hydroxyl by phosphoseryl- and pyrrolysyl-tRNA synthetases (2013), FEBS Lett., 587, 3360-3364.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.26 ATP + L-pyrrolysine + tRNAPyl Methanosarcina barkeri the enzyme attaches attaches L-pyrrolysine only to tRNA transcripts with a 3'-OH group at A76, whereas no aminoacylation at the 2'-OH group is detected AMP + diphosphate + L-pyrrolysyl-tRNAPyl
-
 ?
6.1.1.26 ATP + L-pyrrolysine + tRNAPyl Desulfitobacterium hafniense the enzyme attaches L-pyrrolysine only to tRNA transcripts with a 3'-OH group at A76, whereas no aminoacylation at the 2'-OH group is detected AMP + diphosphate + L-pyrrolysyl-tRNAPyl
-
 ?
6.1.1.27 ATP + O-phospho-L-serine + tRNACys Methanococcus maripaludis the enzyme charges tRNACys with a 3'-deoxyadenosine, but not tRNACys without A76 or with a 2'-deoxyadensosine AMP + diphosphate + O-phospho-L-seryl-tRNACys
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.26 Desulfitobacterium hafniense
-
-
-
6.1.1.26 Methanosarcina barkeri
-
-
-
6.1.1.27 Methanococcus maripaludis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.26 ATP + L-pyrrolysine + tRNAPyl the enzyme attaches attaches L-pyrrolysine only to tRNA transcripts with a 3'-OH group at A76, whereas no aminoacylation at the 2'-OH group is detected Methanosarcina barkeri AMP + diphosphate + L-pyrrolysyl-tRNAPyl
-
 ?
6.1.1.26 ATP + L-pyrrolysine + tRNAPyl the enzyme attaches L-pyrrolysine only to tRNA transcripts with a 3'-OH group at A76, whereas no aminoacylation at the 2'-OH group is detected Desulfitobacterium hafniense AMP + diphosphate + L-pyrrolysyl-tRNAPyl
-
 ?
6.1.1.27 ATP + O-phospho-L-serine + tRNACys the enzyme charges tRNACys with a 3'-deoxyadenosine, but not tRNACys without A76 or with a 2'-deoxyadensosine Methanococcus maripaludis AMP + diphosphate + O-phospho-L-seryl-tRNACys
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.26 PylRS
-
 Methanosarcina barkeri
6.1.1.26 PylRS
-
 Desulfitobacterium hafniense
6.1.1.26 pyrrolysyl-tRNA synthetase
-
 Methanosarcina barkeri
6.1.1.26 pyrrolysyl-tRNA synthetase
-
 Desulfitobacterium hafniense
6.1.1.27 O-phosphoseryl-tRNA synthetase
-
 Methanococcus maripaludis
6.1.1.27 SepRS
-
 Methanococcus maripaludis

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.26 ATP
-
 Methanosarcina barkeri
6.1.1.26 ATP
-
 Desulfitobacterium hafniense
6.1.1.27 ATP
-
 Methanococcus maripaludis