EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.99.1 | glutathione | promotes prostaglandin H synthase-dependent formation of oxidative stress biomarkers malondialdehyde and 15(S)-8-iso-prostaglandin F2alpha | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.99.1 | arachidonate + AH2 + 2 O2 | Homo sapiens | - |
prostaglandin G2 + A + ? | - |
? | |
1.14.99.1 | arachidonate + AH2 + 2 O2 | Homo sapiens | - |
prostaglandin H2 + A + H2O | - |
? | |
1.14.99.1 | additional information | Homo sapiens | activity with arachidonate in presence of glutathione leads to formation of malondialdehyde and (15S)-8-iso-prostaglandin F2alpha | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.99.1 | Homo sapiens | P23219 | - |
- |
1.14.99.1 | Homo sapiens | P35354 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.99.1 | arachidonate + AH2 + 2 O2 | - |
Homo sapiens | prostaglandin G2 + A + ? | - |
? | |
1.14.99.1 | arachidonate + AH2 + 2 O2 | - |
Homo sapiens | prostaglandin H2 + A + H2O | - |
? | |
1.14.99.1 | additional information | activity with arachidonate in presence of glutathione leads to formation of malondialdehyde and (15S)-8-iso-prostaglandin F2alpha | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.99.1 | COX | - |
Homo sapiens |
1.14.99.1 | COX-1 | - |
Homo sapiens |
1.14.99.1 | COX-2 | - |
Homo sapiens |
1.14.99.1 | cyclooxygenase | - |
Homo sapiens |
1.14.99.1 | cyclooxygenase-1 | - |
Homo sapiens |
1.14.99.1 | cyclooxygenase-2 | - |
Homo sapiens |
1.14.99.1 | PG H synthase | - |
Homo sapiens |
1.14.99.1 | PGHS | - |
Homo sapiens |
1.14.99.1 | PGHS-1 | - |
Homo sapiens |
1.14.99.1 | PGHS-2 | - |
Homo sapiens |
1.14.99.1 | prostaglandin H synthase | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.99.1 | physiological function | prostaglandin H synthases or cyclooxygenases catalyse the peroxidation of arachidonic acid to PGG2 and PGH2 which are further converted to a series of prostaglandins and thromboxane A2. The enzyme catalyzes formation of oxidative stress biomarkers malondialdehyde and 15(S)-8-iso-prostaglandin F2alpha, and other F2-isoprostanes, promoted by glutathione | Homo sapiens |