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Literature summary extracted from

  • Tsikas, D.; Suchy, M.T.; Niemann, J.; Tossios, P.; Schneider, Y.; Rothmann, S.; Gutzki, F.M.; Froelich, J.C.; Stichtenoth, D.O.
    Glutathione promotes prostaglandin H synthase (cyclooxygenase)-dependent formation of malondialdehyde and 15(S)-8-iso-prostaglandin F2? (2012), FEBS Lett., 586, 3723-3730.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.99.1 glutathione promotes prostaglandin H synthase-dependent formation of oxidative stress biomarkers malondialdehyde and 15(S)-8-iso-prostaglandin F2alpha Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.1 arachidonate + AH2 + 2 O2 Homo sapiens
-
prostaglandin G2 + A + ?
-
?
1.14.99.1 arachidonate + AH2 + 2 O2 Homo sapiens
-
prostaglandin H2 + A + H2O
-
?
1.14.99.1 additional information Homo sapiens activity with arachidonate in presence of glutathione leads to formation of malondialdehyde and (15S)-8-iso-prostaglandin F2alpha ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.1 Homo sapiens P23219
-
-
1.14.99.1 Homo sapiens P35354
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.1 arachidonate + AH2 + 2 O2
-
Homo sapiens prostaglandin G2 + A + ?
-
?
1.14.99.1 arachidonate + AH2 + 2 O2
-
Homo sapiens prostaglandin H2 + A + H2O
-
?
1.14.99.1 additional information activity with arachidonate in presence of glutathione leads to formation of malondialdehyde and (15S)-8-iso-prostaglandin F2alpha Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.1 COX
-
Homo sapiens
1.14.99.1 COX-1
-
Homo sapiens
1.14.99.1 COX-2
-
Homo sapiens
1.14.99.1 cyclooxygenase
-
Homo sapiens
1.14.99.1 cyclooxygenase-1
-
Homo sapiens
1.14.99.1 cyclooxygenase-2
-
Homo sapiens
1.14.99.1 PG H synthase
-
Homo sapiens
1.14.99.1 PGHS
-
Homo sapiens
1.14.99.1 PGHS-1
-
Homo sapiens
1.14.99.1 PGHS-2
-
Homo sapiens
1.14.99.1 prostaglandin H synthase
-
Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.99.1 physiological function prostaglandin H synthases or cyclooxygenases catalyse the peroxidation of arachidonic acid to PGG2 and PGH2 which are further converted to a series of prostaglandins and thromboxane A2. The enzyme catalyzes formation of oxidative stress biomarkers malondialdehyde and 15(S)-8-iso-prostaglandin F2alpha, and other F2-isoprostanes, promoted by glutathione Homo sapiens