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Literature summary extracted from
- Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2-hydroxybenzanilides, their thioxo analogues and benzoxazoles (2012), Eur. J. Med. Chem., 56, 108-119.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.3.1 | 2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate | - |
Mycobacterium avium |  |
| 4.1.3.1 | 2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole | - |
Mycobacterium avium | |
| 4.1.3.1 | 2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate | - |
Mycobacterium avium | |
| 4.1.3.1 | 2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole | - |
Mycobacterium avium | |
| 4.1.3.1 | 2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate | - |
Mycobacterium avium | |
| 4.1.3.1 | 4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium avium | |
| 4.1.3.1 | 5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium avium | |
| 4.1.3.1 | 5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | 5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium avium | |
| 4.1.3.1 | 6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium avium | |
| 4.1.3.1 | 6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | 6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium avium | |
| 4.1.3.1 | 6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium kansasii | |
| 4.1.3.1 | 6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | additional information | design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview | Mycobacterium avium | |
| 4.1.3.1 | additional information | design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview | Mycobacterium kansasii | |
| 4.1.3.1 | additional information | design, synthesis, inhibitory potencies against the enzyme, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview | Mycobacterium tuberculosis | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide | - |
Mycobacterium avium | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide | - |
Mycobacterium tuberculosis | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide | - |
Mycobacterium avium | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide | - |
Mycobacterium kansasii | |
| 4.1.3.1 | N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide | - |
Mycobacterium tuberculosis | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.3.1 | isocitrate | Mycobacterium avium | - |
succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | Mycobacterium tuberculosis | - |
succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | Mycobacterium kansasii | - |
succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | Mycobacterium kansasii My 235/80 | - |
succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | Mycobacterium avium My 330/88 | - |
succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | Mycobacterium kansasii 6509/96 | - |
succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | Mycobacterium tuberculosis My 331/88 | - |
succinate + glyoxylate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.3.1 | Mycobacterium avium | - |
- |
- |
| 4.1.3.1 | Mycobacterium avium My 330/88 | - |
- |
- |
| 4.1.3.1 | Mycobacterium kansasii | - |
- |
- |
| 4.1.3.1 | Mycobacterium kansasii 6509/96 | - |
- |
- |
| 4.1.3.1 | Mycobacterium kansasii My 235/80 | - |
- |
- |
| 4.1.3.1 | Mycobacterium tuberculosis | - |
- |
- |
| 4.1.3.1 | Mycobacterium tuberculosis My 331/88 | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.3.1 | isocitrate | - |
Mycobacterium avium | succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | - |
Mycobacterium tuberculosis | succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | - |
Mycobacterium kansasii | succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | - |
Mycobacterium kansasii My 235/80 | succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | - |
Mycobacterium avium My 330/88 | succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | - |
Mycobacterium kansasii 6509/96 | succinate + glyoxylate | - |
? | |
| 4.1.3.1 | isocitrate | - |
Mycobacterium tuberculosis My 331/88 | succinate + glyoxylate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.3.1 | ICL | - |
Mycobacterium avium |
| 4.1.3.1 | ICL | - |
Mycobacterium tuberculosis |
| 4.1.3.1 | ICL | - |
Mycobacterium kansasii |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.1.3.1 | 37 | - |
assay at | Mycobacterium avium |
| 4.1.3.1 | 37 | - |
assay at | Mycobacterium tuberculosis |
| 4.1.3.1 | 37 | - |
assay at | Mycobacterium kansasii |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.3.1 | 7 | - |
assay at | Mycobacterium avium |
| 4.1.3.1 | 7 | - |
assay at | Mycobacterium tuberculosis |
| 4.1.3.1 | 7 | - |
assay at | Mycobacterium kansasii |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 4.1.3.1 | 0.00298 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide | |
| 4.1.3.1 | 0.00314 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.00316 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.00369 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.00372 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.00388 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.0039 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide | |
| 4.1.3.1 | 0.00409 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide | |
| 4.1.3.1 | 0.00445 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.00491 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide | |
| 4.1.3.1 | 0.00511 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.00563 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide | |
| 4.1.3.1 | 0.00574 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.00586 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.00653 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.00734 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide | |
| 4.1.3.1 | 0.0076 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.00798 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide | |
| 4.1.3.1 | 0.00849 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.0086 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.00874 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide | |
| 4.1.3.1 | 0.01152 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide | |
| 4.1.3.1 | 0.01543 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide | |
| 4.1.3.1 | 0.02537 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide | |
| 4.1.3.1 | 0.04662 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide | |
| 4.1.3.1 | 0.0513 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide | |
| 4.1.3.1 | 0.08702 | - |
pH 7.0, 37°C | Mycobacterium tuberculosis | 4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide | |
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Release 2023.1 (January 2023)
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