BRENDA - Enzyme Database

Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2-hydroxybenzanilides, their thioxo analogues and benzoxazoles

Kozic, J.; Novotna, E.; Volkova, M.; Stolarikova, J.; Trejtnar, F.; Wsol, V.; Vinsova, J.; Eur. J. Med. Chem. 56, 108-119 (2012)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.3.1
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium avium
4.1.3.1
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
4.1.3.1
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
4.1.3.1
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium avium
4.1.3.1
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
4.1.3.1
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
4.1.3.1
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium avium
4.1.3.1
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
4.1.3.1
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium avium
4.1.3.1
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
4.1.3.1
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
additional information
design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium avium
4.1.3.1
additional information
design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium kansasii
4.1.3.1
additional information
design, synthesis, inhibitory potencies against the enzyme, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium tuberculosis
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.1.3.1
isocitrate
Mycobacterium avium
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium tuberculosis
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium kansasii
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium kansasii My 235/80
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium avium My 330/88
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium kansasii 6509/96
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium tuberculosis My 331/88
-
succinate + glyoxylate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.1.3.1
Mycobacterium avium
-
-
-
4.1.3.1
Mycobacterium avium My 330/88
-
-
-
4.1.3.1
Mycobacterium kansasii
-
-
-
4.1.3.1
Mycobacterium kansasii 6509/96
-
-
-
4.1.3.1
Mycobacterium kansasii My 235/80
-
-
-
4.1.3.1
Mycobacterium tuberculosis
-
-
-
4.1.3.1
Mycobacterium tuberculosis My 331/88
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.3.1
isocitrate
-
727419
Mycobacterium avium
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium tuberculosis
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium kansasii
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium kansasii My 235/80
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium avium My 330/88
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium kansasii 6509/96
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium tuberculosis My 331/88
succinate + glyoxylate
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
4.1.3.1
37
-
assay at
Mycobacterium avium
4.1.3.1
37
-
assay at
Mycobacterium kansasii
4.1.3.1
37
-
assay at
Mycobacterium tuberculosis
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.1.3.1
7
-
assay at
Mycobacterium avium
4.1.3.1
7
-
assay at
Mycobacterium kansasii
4.1.3.1
7
-
assay at
Mycobacterium tuberculosis
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
4.1.3.1
0.00298
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
4.1.3.1
0.00314
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
4.1.3.1
0.00316
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.00369
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
4.1.3.1
0.00372
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.00388
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
4.1.3.1
0.0039
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
4.1.3.1
0.00409
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
4.1.3.1
0.00445
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.00491
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
4.1.3.1
0.00511
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.00563
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
4.1.3.1
0.00574
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
4.1.3.1
0.00586
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
4.1.3.1
0.00653
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
4.1.3.1
0.00734
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
4.1.3.1
0.0076
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
4.1.3.1
0.00798
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
4.1.3.1
0.00849
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.0086
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.00874
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
4.1.3.1
0.01152
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
4.1.3.1
0.01543
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
4.1.3.1
0.02537
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
4.1.3.1
0.04662
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
4.1.3.1
0.0513
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
4.1.3.1
0.08702
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
4.1.3.1
0.00298
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
4.1.3.1
0.00314
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
4.1.3.1
0.00316
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.00369
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
4.1.3.1
0.00372
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.00388
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
4.1.3.1
0.0039
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
4.1.3.1
0.00409
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
4.1.3.1
0.00445
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.00491
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
4.1.3.1
0.00511
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.00563
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
4.1.3.1
0.00574
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
4.1.3.1
0.00586
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
4.1.3.1
0.00653
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
4.1.3.1
0.00734
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
4.1.3.1
0.0076
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
4.1.3.1
0.00798
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
4.1.3.1
0.00849
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.0086
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
4.1.3.1
0.00874
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
4.1.3.1
0.01152
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
4.1.3.1
0.01543
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
4.1.3.1
0.02537
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
4.1.3.1
0.04662
-
pH 7.0, 37°C
Mycobacterium tuberculosis
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
4.1.3.1
0.0513
-
pH 7.0, 37°C
Mycobacterium tuberculosis
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
4.1.3.1
0.08702
-
pH 7.0, 37°C
Mycobacterium tuberculosis
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.3.1
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium avium
4.1.3.1
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
4.1.3.1
2-(4-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
4.1.3.1
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
2-(4-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium avium
4.1.3.1
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
4.1.3.1
2-(5-chloro-2-methoxybenzamido)-5-(trifluoromethyl)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
4.1.3.1
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
2-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium avium
4.1.3.1
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
4.1.3.1
4,5-dichloro-2-(5-chloro-2-methoxybenzamido)phenyl 5-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
4-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
5,6-dichloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
5,6-dichloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
5-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
5-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium avium
4.1.3.1
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium kansasii
4.1.3.1
5-chloro-2-(4-chloro-2-methoxybenzamido)phenyl 4-chloro-2-methoxybenzoate
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
5-chloro-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(2-hydroxy-4-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(2-hydroxy-5-(trifluoromethyl)phenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(4,5-dichloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(4-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
5-chloro-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
6-bromo-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
6-bromo-2-(5-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium avium
4.1.3.1
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium kansasii
4.1.3.1
6-chloro-2-(4-chloro-2-methoxyphenyl)benzo[d]oxazole
-
Mycobacterium tuberculosis
4.1.3.1
additional information
design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium avium
4.1.3.1
additional information
design, synthesis, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium kansasii
4.1.3.1
additional information
design, synthesis, inhibitory potencies against the enzyme, and in vitro antimycobacterial activities against human hepatic cells of a series of 2-methoxy-2'-hydroxybenzanilide derivatives and their thioxo analogues, overview
Mycobacterium tuberculosis
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
N-(4-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-4-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium avium
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium kansasii
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzamide
-
Mycobacterium tuberculosis
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium avium
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium kansasii
4.1.3.1
N-(5-bromo-2-hydroxyphenyl)-5-chloro-2-methoxybenzothioamide
-
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.1.3.1
isocitrate
Mycobacterium avium
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium tuberculosis
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium kansasii
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium kansasii My 235/80
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium avium My 330/88
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium kansasii 6509/96
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium tuberculosis My 331/88
-
succinate + glyoxylate
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.3.1
isocitrate
-
727419
Mycobacterium avium
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium tuberculosis
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium kansasii
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium kansasii My 235/80
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium avium My 330/88
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium kansasii 6509/96
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
727419
Mycobacterium tuberculosis My 331/88
succinate + glyoxylate
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
4.1.3.1
37
-
assay at
Mycobacterium avium
4.1.3.1
37
-
assay at
Mycobacterium kansasii
4.1.3.1
37
-
assay at
Mycobacterium tuberculosis
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.1.3.1
7
-
assay at
Mycobacterium avium
4.1.3.1
7
-
assay at
Mycobacterium kansasii
4.1.3.1
7
-
assay at
Mycobacterium tuberculosis