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Literature summary extracted from

  • Qi, J.; Oppenheimer, M.; Sobrado, P.
    Fluorescence polarization binding assay for Aspergillus fumigatus virulence factor UDP-galactopyranose mutase (2011), Enzyme Res., 2011, 513905.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.4.99.9 drug development inhibitors of the enzyme that block the biosynthesis of UDP-galactofuranose can lead to novel chemotherapeutics for treating Aspergillus fumigatus-related diseases Aspergillus fumigatus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.9 (Z)-N-((E)-5-(5-nitro-2-oxoindolin-3-ylidene)-4-oxothiazolidin-2-ylidene) benzenesulfonamide
-
Aspergillus fumigatus
5.4.99.9 2-(2-(4-bromophenyI)-1, 3-dioxoisoindolin-5-carboxamido) benzoic acid
-
Aspergillus fumigatus
5.4.99.9 UDP competitive Aspergillus fumigatus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.4.99.9 additional information
-
additional information high-affinity binding to the enzyme is only obtained with the chromophore 5-carboxytetramethylrhodamine, i.e. TAMRA, linked to UDP by either 2 or 6 carbons, 6times less when UDP is linked to fluorescein, kinetics, overview Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.9 UDP-alpha-D-galactopyranose Aspergillus fumigatus
-
UDP-alpha-D-galactofuranose
-
r

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.9 Aspergillus fumigatus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.9 additional information development of a fluorescence polarization binding assay for the Aspergillus fumigatus enzyme, evaluation, overview Aspergillus fumigatus ?
-
?
5.4.99.9 UDP-alpha-D-galactopyranose
-
Aspergillus fumigatus UDP-alpha-D-galactofuranose
-
r

Synonyms

EC Number Synonyms Comment Organism
5.4.99.9 UGM
-
Aspergillus fumigatus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.4.99.9 37
-
assay at Aspergillus fumigatus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.4.99.9 7.5
-
assay at Aspergillus fumigatus

Cofactor

EC Number Cofactor Comment Organism Structure
5.4.99.9 flavin flavoenzyme Aspergillus fumigatus

General Information

EC Number General Information Comment Organism
5.4.99.9 physiological function UDP-galactopyranose mutase catalyzes the isomerization of UDP-galactopyranose to UDP-galactofuranose, the biosynthetic precursor of galactofuranose residues, which are essential components of the cell wall and play an important role in Aspergillus fumigatus virulence Aspergillus fumigatus