Literature summary extracted from

Edwards, T.E.; Abramov, A.B.; Smith, E.R.; Baydo, R.O.; Leonard, J.T.; Leibly, D.J.; Thompkins, K.B.; Clifton, M.C.; Gardberg, A.S.; Staker, B.L.; Van Voorhis, W.C.; Myler, P.J.; Stewart, L.J.
Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis (2011), BMC Struct. Biol., 11, 39.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
5.3.1.6	expressed in Escherichia coli BL21 (DE3) R3 Rosetta cells	Coccidioides immitis

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
5.3.1.6	co-crystallization in the presence of 20 mM ribose-5-phosphate or 20 mM ribose-5-phosphate with 12 mM MnCl2, sitting drop vapor diffusion method, using 0.1 M Na citrate pH 5.0, 20% (w/v) PEG 6000	Coccidioides immitis

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.3.1.6	iodoacetic acid	suicide inhibitor	Coccidioides immitis

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5.3.1.6	D-ribose 5-phosphate	Coccidioides immitis	-	D-ribulose 5-phosphate	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.3.1.6	Coccidioides immitis	P0CL19	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
5.3.1.6	Ni-NTA column chromatography and Superdex 75 gel filtration	Coccidioides immitis

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.3.1.6	D-ribose 5-phosphate	-	Coccidioides immitis	D-ribulose 5-phosphate	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
5.3.1.6	ribose-5-phosphate isomerase B	-	Coccidioides immitis
5.3.1.6	RpiB	-	Coccidioides immitis

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Release 2023.1 (January 2023)